N,n'-bis-(aminoalkyl)-benzyl-amines
Abstract
Abstract N,N1 - (IMINODIALKYLENE)BENZENESULFONAMIDES, N,N1(ALKYLENEDIIMINODIALKYLENE)BENZENESULFONAMIDES AND DERIVATIVES THEREOF, EFFECTIVE AGAINST TACHYCARDIA AND ARRHYTHMIA IN BOTH AURICULAR AND VENTRICULAR TISSUES, ARE PREPARED, FOR EXAMPLE, FROM AN INTERMEDIATE OF THE FORMULA (4-R1''-PHENYL)-SO2-N(-R2)-CH2-(CH2)N1-NH2 (4-R4''-PHENYL)-SO2-N(-R2)-CH2-(CH2)P1-X (4-R1''-PHENYL)-SO2-N(-R2)-C(-R3)2-(CH2)N-NH- (CH2)M1-NH2 OR PHENYL-CH2-N(-(CH2)N1-CH2-NH2)-(CH2)P1-CH2-NH2 WHEREIN R1'' AND R4'' ARE HYDROGEN, LOWER ALKYL, PROTECTED AMINO GROUP OR AMINO GROUP PRECURSOR; R2 AND R3 ARE HYDROGEN OR LOWER ALKYL; X IS CHLORINE OR BROMINE; N1 AND P1 ARE EACH 2 OR 3; N IS FROM 1 TO 3, AND M1 IS FROM 2 TO 4.
Inventors
- 👤 Vsevolod Gruenman
- 👤 Max Hoffer
- 👤 Jay Philip O'brien
- 👤 Albert Israel Rachlin
- 👤 Gerhard Zbinden
Bibliographic Details
Claims Analysis
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