Tertiary aminopropyl beta-quaternary 3,4,5-trimethoxybenzoates
Abstract
Abstract THE SPECIFICATION DISCLOSES TERTIARY AMINO PROPYL BQUATERNARY ESTERS OF 3,4,5-TRIMETHOXYBENZOIC ACID THAT EXHIBIT A HIGH CNS DAMPING EFFECT, IN THE FORM OF SEDATIVE, CORONORY BLOOD VESSEL ENLARGING, BLOOD PRESSURE REDUCING, INTESTINAL SPASMOLYTIC PROPERTIES, AND THE RESPECTIVE THERAPEUTIC INDICES ARE EXCELLENT AND TOXICITY LOW. THE ESTERS OF THE INVENTION HAVE THE GENERAL FORMULA: (3,4,5-TRI(CH3-O-)PHENYL)-COO-CH2-C(-R1)(-R2)-CH2-B IN WHICH R1 AND R2 REPRESENT ALKYL (AT LEAST ONE OF WHICH IS GREATER THAN METHYL), ARALKYL OR ARYL RESIDUES, AND B REPRESENTS A DIALKYL AMINO RESIDUE, A SATURATED N-HETEROCYCLIC RING, OR A MORPHOLINO GROUP, R1 AND R2 MAY REPRESENT, FOR INSTANCE THE FOLLOWING SUBSITUTION PAIRS: METHYL-PROPYL, EHTYL-ETHYL, ETHYL-BENZYL AND ETHYL-PHENYL, B MAY REPRESENT, FOR EXAMPLE, DIMETHYL AMINO, DIETHYL AMINO, PYRROLIDINO, PIPERIDINO OR MORPHOLINO GROUPS.
Inventors
- 👤 Kurt Schmidt
- 👤 Ernest Gunther
Bibliographic Details
Claims Analysis
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