Production of aminoacylpenicillins
Abstract
Abstract AMINOACYLPENICILLINS OF THE FORMULA: 2-(HOOC-),3,3-DI(CH3-),6-(R-CH(-NH2)-CO-NH-)PENAM ARE PRODUCED BY REACTING AN N-PROTECTED PENICILLIN OF THE FORMULA: 2-(HOOC-),3,3-DI(CH3-),6-(R1-SO2-X-OOC-NH-CH(-R)-CO-NH-)- PENAM WHEREIN R IS A SUBSTITUTED OR UNSUBSTITUTED ALKYL, ARALKYL, ARYL OR HETEROCYCLIC GROUP, R1 IS A SUBSTITUTED OR UNSUBSTITUTED ALKYL, ARALKYL OR ARYL GROUP, AND X IS A DIVALENT SATURATED HYDROCARBON MOIETY HAVING FROM 2 TO 6 CARBON ATOMS LINKED TO THE GROUPS ON EITHER SIDE THROUGH ADJACENT CARBON ATOMS, WITH A SUITABLE BASE IN AN AQUEOUS OR PARTIALLY AQUEOUS SOLUTION AT A PH BETWEEN 8 AND 11.5 AND AT A TEMPERATURE BETWEEN 0*C. AND 50*C. NON-TOXIC PHARMACEUTICALLY ACCEPTABLE SALTS ALSO FORM PART OF THE PRESENT INVENTION.
Inventors
- 👤 Brian William Hatt
- 👤 Harry Smith
Bibliographic Details
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