US3093545A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Therapeutic iron-dextran preparations
Assignee: SCHERING PURCHASE Corp
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Filing: 1960-08-29
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Granted: 1963-06-11
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Expires: 1980-08-29
Abstract
No abstract record available.
Inventors
- 👤 Robert J Westfall
- 👤 Sheldon H Lewis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 17:39
CPC Classifications
A; A61; A61K; A61K33/00; A61K33/24; A61K33/26; A61K31/00; A61K31/28; A61K31/295
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
133 words
AN IRON PREPARATION FOR THERAPEUTIC PURPOSES, COMPRISNG AN AQUEOUS SOLUTION OF A COMPLEX IRON AND DESTRAN, WHICH COMPLEX DEMONSTRATES AN AVERAGE INSTRINSIC VISCOSITY AT A TEMPERATURE OF 25*C. OF FROM 0.025 TO 0.25, WHIC COMPLEX DEMONSTRATES IN AQUEOUS SOLUTION AT AN IRON CONCENTRATION OF 10 MG. PER ML. AT A TEMPERATURE OF 25*C. KINEMATIC VISCOSITY OF LESS THAN 45 CENTISTOKES, WHICH COMPLEX IS SUBSTANTIALLY FREE FROM DEXTRAN DEGRADATION PRODUCTS HAVING MOLECULAR WEIGHTS OF LESS THAN 300, WHICH COMPLEX DEMONSTRATES ON INTRAVENOUS ADMINISTRATION OF MICE AN LD50 OF AT LAST 1500 MG. FE PER KG., AND WHICH COMPLEX DEMONSTRATES, ON INTRAMUSCULAR INJECTION INTO THE HIND LEG OF A RABBIT AT A DOSE CONCENTRATION OF 20 MG. OF IRON PERKG. OF BODY WEIGHT, LESS THAN 20% RESIDUAL IRON AT THE INJECTION SITE AFTER SEVEN DAYS.
Claim 2
Dependent Claim
133 words
AN IRON PREPARATION FOR THERAPEUTIC PURPOSES, COMPRISNG AN AQUEOUS SOLUTION OF A COMPLEX IRON AND DESTRAN, WHICH COMPLEX DEMONSTRATES AN AVERAGE INSTRINSIC VISCOSITY AT A TEMPERATURE OF 25*C. OF FROM 0.025 TO 0.25, WHIC COMPLEX DEMONSTRATES IN AQUEOUS SOLUTION AT AN IRON CONCENTRATION OF 10 MG. PER ML. AT A TEMPERATURE OF 25*C. KINEMATIC VISCOSITY OF LESS THAN 45 CENTISTOKES, WHICH COMPLEX IS SUBSTANTIALLY FREE FROM DEXTRAN DEGRADATION PRODUCTS HAVING MOLECULAR WEIGHTS OF LESS THAN 300, WHICH COMPLEX DEMONSTRATES ON INTRAVENOUS ADMINISTRATION OF MICE AN LD50 OF AT LAST 1500 MG. FE PER KG., AND WHICH COMPLEX DEMONSTRATES, ON INTRAMUSCULAR INJECTION INTO THE HIND LEG OF A RABBIT AT A DOSE CONCENTRATION OF 20 MG. OF IRON PERKG. OF BODY WEIGHT, LESS THAN 20% RESIDUAL IRON AT THE INJECTION SITE AFTER SEVEN DAYS.
Claim 3
Dependent Claim
90 words
IN AMETHOD OF PREPARING AN IRON PRODUCT FOR THERAPEUTIC PURPOSES, THE STEPS OF FORMING AN AQUEOUS SOLUTION HAVNG A PH OF LESS THAN ABOUT 2.3 OF DEXTRAN HAVING AN AVERAGE INSTRINSIC VISCOSITY OF FROM 0.25 TO 0.25 AND AT LEAST ONE WATER-SOLUBLE FERRIC SALT, AND ADJUSTING THE RESULTING AQUEOUS SOLUTION TO A PH OF FROM 3.5 TO 5.0 OVER A PERIOD OF AT LEAST ONE-HALF HOUR TO OBTAIN THE IRONDEXTRAN COMPLEX, WHILE MAINTAINING SAID AQUEOUS SOLUTION DURING THE FORMATION OF THE IRON-DEXTRAN COMPLEX AT A TEMPERATURE OF LESS THAN 70*C.
Claim 4
Dependent Claim
90 words
IN AMETHOD OF PREPARING AN IRON PRODUCT FOR THERAPEUTIC PURPOSES, THE STEPS OF FORMING AN AQUEOUS SOLUTION HAVNG A PH OF LESS THAN ABOUT 2.3 OF DEXTRAN HAVING AN AVERAGE INSTRINSIC VISCOSITY OF FROM 0.25 TO 0.25 AND AT LEAST ONE WATER-SOLUBLE FERRIC SALT, AND ADJUSTING THE RESULTING AQUEOUS SOLUTION TO A PH OF FROM 3.5 TO 5.0 OVER A PERIOD OF AT LEAST ONE-HALF HOUR TO OBTAIN THE IRONDEXTRAN COMPLEX, WHILE MAINTAINING SAID AQUEOUS SOLUTION DURING THE FORMATION OF THE IRON-DEXTRAN COMPLEX AT A TEMPERATURE OF LESS THAN 70*C.
References Cited (Backward Citations)
USRE24642E
Cited
US2820740A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1966-06-10 | 1966-12-10 | 1967-06-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1970-06-10 | 1970-12-10 | 1971-06-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1974-06-10 | 1974-12-10 | 1975-06-11 | $7700.00 | Window Closed / Lapsed |