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US3065147A
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US
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Fermentative production and recovery of an antibiotic
Assignee: FARMACENTICI ITALIA Soc
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Filing: 1960-03-29
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Granted: 1962-11-20
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Expires: 1980-03-29
Abstract
No abstract record available.
Inventors
- 👤 Arcamone Federico
- 👤 Ghione Mario
- 👤 Scotti Tullio
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 23:56
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/20; C07H15/22; C07H15/222; C07H15/226; C07H15/228; C07H15/232; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/886
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
142 words
A PROCESS FOR PRODUCING AN ANTIBIOTIC SUBSTANCE, WHICH COMPRISES CULTIVATING STREPTOMYCES KRESTOMYCETICUS N.C.I.B. 8995 AND COMMONWEATH MYCOLOGICAL INSTITUTE NO. 79589 IN AN AQUEOUS NUTRIENT MEDIUM CONTAINING A SOURCE OF CARBON, NITROGEN AND MINERAL SALTS UNDER AEROBIC CONDITIONS UNTIL SUBSTANTIAL ANTI-BACTERIAL ACTIVITY IS IMPARTED TO THE MEDIUM, AND THEN RECOVERING THE ANTIBIOTIC FROM THE MEDIUM, SAID ANTIBIOTIC HAVING A BROAD SPECTRUM OF ANTIBACTERIAL ACTIVITY AGAINST GRAM-POSITIVE AND GRAMNEGATIVE, AND PARTICULARLY AGAINST STAPHYLOCOCCI KNOW TO THE RESISTANT TO OTHER ANTIBIOTICS, HAVING A BASIC CHARACTER, AN EMPIRICAL FORMULA C23H45N5O14, GIVING A PENTAACYL DERIVATIVE BY ACYLATION, GIVING A SILFATE WHICH IS A WHITE POWDER SOLUBLE IN WATER AND INSOLUBLE IN ALMOST ALL ORGANIC SOLVENT, THE SAID SULFATE HAVING CHARACTERISTIC ABSORPTION IN THE INFRARED REGION WHEN SUSPENDED IN POTASSIUM BROMIDE SOLUTION WITH PRONOUNCED PEAKS AT THE FOLLOWING WAVE LENGHTS IN U, 2.94, 3.41, 6.15, 6.55, 9.00 AND
Claim 2
Dependent Claim
142 words
A PROCESS FOR PRODUCING AN ANTIBIOTIC SUBSTANCE, WHICH COMPRISES CULTIVATING STREPTOMYCES KRESTOMYCETICUS N.C.I.B. 8995 AND COMMONWEATH MYCOLOGICAL INSTITUTE NO. 79589 IN AN AQUEOUS NUTRIENT MEDIUM CONTAINING A SOURCE OF CARBON, NITROGEN AND MINERAL SALTS UNDER AEROBIC CONDITIONS UNTIL SUBSTANTIAL ANTI-BACTERIAL ACTIVITY IS IMPARTED TO THE MEDIUM, AND THEN RECOVERING THE ANTIBIOTIC FROM THE MEDIUM, SAID ANTIBIOTIC HAVING A BROAD SPECTRUM OF ANTIBACTERIAL ACTIVITY AGAINST GRAM-POSITIVE AND GRAMNEGATIVE, AND PARTICULARLY AGAINST STAPHYLOCOCCI KNOW TO THE RESISTANT TO OTHER ANTIBIOTICS, HAVING A BASIC CHARACTER, AN EMPIRICAL FORMULA C23H45N5O14, GIVING A PENTAACYL DERIVATIVE BY ACYLATION, GIVING A SILFATE WHICH IS A WHITE POWDER SOLUBLE IN WATER AND INSOLUBLE IN ALMOST ALL ORGANIC SOLVENT, THE SAID SULFATE HAVING CHARACTERISTIC ABSORPTION IN THE INFRARED REGION WHEN SUSPENDED IN POTASSIUM BROMIDE SOLUTION WITH PRONOUNCED PEAKS AT THE FOLLOWING WAVE LENGHTS IN U, 2.94, 3.41, 6.15, 6.55, 9.00 AND
Claim 3
Dependent Claim
92 words
52, WEAK BANDS AT 6.82, 7.08, 7.28, 7.46, 10.70, 11.17, 11.62, AND 13.08 AND INFLECTIONS AT 3.09 AND 10.23, THE OPTICAL ROTATION OF 1% AQUEOUS SOLUTION OF THE SULFATE BEING (A)D20=+51*, GIVING A HYDROCHLORIDE CONTAINING 33.79%C., 6.76% H, 8.17% N AND 21.05% CI, WHICH IS A WHITE POWDER INSOLUBLE IN MOST ORGANIC SOLVENTS EXCEPT METHANOL AND HAS THE OPTICAL ROTATION, IN 1% AQUEOUS SOLUTION, (A)D25=+55*, GIVING A P(P-HYDROXY-PHENYLAZO)BENZENE-SULFONATE CONTAINING 5/.58%C, 5.25% H, 10.27% N AND 7.72% S, AND GIVING A HELIANTHINE SALT CONTAINING 51.29% C, 6.20% H, 12.23% N AND 7.50% S.
Claim 4
Dependent Claim
92 words
52, WEAK BANDS AT 6.82, 7.08, 7.28, 7.46, 10.70, 11.17, 11.62, AND 13.08 AND INFLECTIONS AT 3.09 AND 10.23, THE OPTICAL ROTATION OF 1% AQUEOUS SOLUTION OF THE SULFATE BEING (A)D20=+51*, GIVING A HYDROCHLORIDE CONTAINING 33.79%C., 6.76% H, 8.17% N AND 21.05% CI, WHICH IS A WHITE POWDER INSOLUBLE IN MOST ORGANIC SOLVENTS EXCEPT METHANOL AND HAS THE OPTICAL ROTATION, IN 1% AQUEOUS SOLUTION, (A)D25=+55*, GIVING A P(P-HYDROXY-PHENYLAZO)BENZENE-SULFONATE CONTAINING 5/.58%C, 5.25% H, 10.27% N AND 7.72% S, AND GIVING A HELIANTHINE SALT CONTAINING 51.29% C, 6.20% H, 12.23% N AND 7.50% S.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1965-11-19 | 1966-05-21 | 1966-11-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1969-11-19 | 1970-05-21 | 1970-11-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1973-11-19 | 1974-05-21 | 1974-11-20 | $7700.00 | Window Closed / Lapsed |