Process for the production of 3,5-diaminopyrazine-2.6-dicarboxylic acid derivatives

Claim 1

A PROCESS FOR THE PRODUCTION OF 3.5-DIAMINO-PYRAZINE-2,6-CICARBOXYLIC ACID AMIDES WHICH COMPRISES CONDENSING ONE MOLECULAR PROPORTION OF 1.3-DIALKYL-4-AMINO URACIL WITH SUBSTANTIALLY ONE MOLECULAR PROPORTION OF 1.3DIALKYL-4-AMINO-5-NITROSO URACIL IN AN ACIDIC MEDIUM WHILE SPLITTING OFF WATER AND AMMONIA TO FORM 3.2.;5.6-BIS((1''.3''RAMIDINO)-PYRAZINE AND SAPONIFYING THIS COMPOUND WITH AN ALKALI METAL HYDROXIDE TO FROM THE 3.5-DIAMINO-PYRAZINE-2.6-DICARBOXYLIC ACID AMIDE WHILE SPLITTING OFF TWO MOLECULAR PROPORTIONS OF CARBONIC ACID AND TRANSFORMING ANY CARBOXYLIC ACID GROUP FORMED DURING SAID ALKALINE TREATMENT INTO A CARBOXYLIC ACID AMIDE GROUP BY TREATING SAID SAPONIFICATION PRODUCT WITH A MEMBER SELECTED FROM THE GROUP CONSISTING OF THIONYL CHLORIDE, PHOSPHORUS TRICHLORIDE AND PHSOPHORUS TRIBROMIDE TO FORM THE CORRESPONDING CARBOXYLIC ACID HALIDE AND TREATING SAID CARBOXYLIC ACID HALIDE WITH A MEMBER SELECTED FROM THE GROUP CONSISTING OF AMMONIA, PRIMARY ALKYL AMINE, LOWER PRIMARY ALKENYLAMINE, LOWER PRIMARY HYDROXYALKYLAMINE, PRIMARY PHENYL-LOWER ALKYLAMINE, PRIMARY CYCLOHEXYLAMINE, PRIMARY PHENYLAMINE, PRIMARY ALKYLPHENYLAMINE, PRIMARY HALOPHENYLAMINE, PRIMARY ALKOXYPHENYLAMINE, PRIMARY PHENOXYPHENYLAMINE, PRIMARY CARBOXYPHENYLAMINE, PRIMARY SULPHOPHENYLAMINE, PRIMARY SULPHAMYLPHENYLAMINE, PRIMARY PYRAZOLYLAMINE, PRIMARY THIAZOLYLAMINE, PRIMARY THIADIAZOLYLAMINE, PRIMARY PYRIDYLAMINE, PRIMARY QUINOLYLAMINE, LOWER ALKYLUREA, BENZYLUREA AND PHENYLUREA TO FORM THE CORRESPONDING CARBOXYLIC ACID AMIDE.