US3011947A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Separation of spiramycins by countercurrent distribution
Assignee: Rhone Poulenc SA
•
Filing: 1956-01-12
•
Granted: 1961-12-05
•
Expires: 1976-01-12
Abstract
No abstract record available.
Inventors
- 👤 Preud Homme Jean
- 👤 Charpentie Yvan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 17:41
CPC Classifications
C; C07; C07H; C07H17/00; C07H17/04; C07H17/08; C12; C12P; C12P17/00; C12P17/18; C12P17/188
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
146 words
PROCESS FOR OBTAINING SEPARATELY SPIRAMYCIN I, SPIRAMYCIN II AND SPIRAMYCIN III WHICH COMPRISES SUBJECTING A CRUDE MATERIAL CONTAINING THE SAME TO COUNTERCURRENT DISTRIBUTION IN A CRAIG COUNTERCURRENT DISTRIBUTION APPARATUS OF 60 CELLS, EFFECTING 59 TRANSFERS AT A TEMPERATURE OF ABOUT 20-25*C. WITH AN ORGANIC PHASE CONSISTING OF BENZENE AND AN AQUEOUS PHASE BUFFERED AT A HYDROGEN-ION CONCENTRATION WITHIN THE RANGE PH 6 TO PH 7, THE TWO PHASES BEING INITIALLY MUTUALLY SATURATED, ISOLATING THE CONSTITUENTS FROM THE ORGANIC PHASE FRACTIONS AFTER RENDERING THOSE FRACTIONS ALKALINE AND EVAPORATING THE SOLVENT, THE SPIRAMYCIN I BEING IN CELLS 5 TO 15, SPIRAMYCIN II BEING IN CELLS 21 TO 28 AND SPIRAMYCIN III BEING IN CELLS 35 TO 45, AND IN THE CASE OF SPIRAMYCINS II AND III SUBJECTING THE PRODUCTS TO FRACTIONAL CRYSTALLISATION BY DISSOLVING THEM IN A HOT AROMATIC HYDROCARBON SOLVENT AND ALLOWING THE RESULTING SOLUTION TO COOL.
Claim 2
Dependent Claim
146 words
PROCESS FOR OBTAINING SEPARATELY SPIRAMYCIN I, SPIRAMYCIN II AND SPIRAMYCIN III WHICH COMPRISES SUBJECTING A CRUDE MATERIAL CONTAINING THE SAME TO COUNTERCURRENT DISTRIBUTION IN A CRAIG COUNTERCURRENT DISTRIBUTION APPARATUS OF 60 CELLS, EFFECTING 59 TRANSFERS AT A TEMPERATURE OF ABOUT 20-25*C. WITH AN ORGANIC PHASE CONSISTING OF BENZENE AND AN AQUEOUS PHASE BUFFERED AT A HYDROGEN-ION CONCENTRATION WITHIN THE RANGE PH 6 TO PH 7, THE TWO PHASES BEING INITIALLY MUTUALLY SATURATED, ISOLATING THE CONSTITUENTS FROM THE ORGANIC PHASE FRACTIONS AFTER RENDERING THOSE FRACTIONS ALKALINE AND EVAPORATING THE SOLVENT, THE SPIRAMYCIN I BEING IN CELLS 5 TO 15, SPIRAMYCIN II BEING IN CELLS 21 TO 28 AND SPIRAMYCIN III BEING IN CELLS 35 TO 45, AND IN THE CASE OF SPIRAMYCINS II AND III SUBJECTING THE PRODUCTS TO FRACTIONAL CRYSTALLISATION BY DISSOLVING THEM IN A HOT AROMATIC HYDROCARBON SOLVENT AND ALLOWING THE RESULTING SOLUTION TO COOL.
References Cited (Backward Citations)
US2378449A
Cited
US2653899A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1964-12-04 | 1965-06-05 | 1965-12-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1968-12-04 | 1969-06-05 | 1969-12-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1972-12-04 | 1973-06-05 | 1973-12-05 | $7700.00 | Window Closed / Lapsed |