US2945785A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of obtaining adrenocortico-tropic hormone preparation of enhanced potency
Assignee: Armour and Co
•
Filing: 1952-09-15
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Granted: 1960-07-19
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Expires: 1972-09-15
Abstract
No abstract record available.
Inventors
- 👤 Wilfrid F White
- 👤 Wendell A Landmann
- 👤 William L Fierce
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 10:05
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/33; A61K38/35
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
152 words
THE CHROMATOGRAPHIC SEPARATION METHOD FOR OBTAINING AN ADRENOCORTICOTROPIC HORMONE PREPARATION OF ENHANCED POTENCY FROM A MIXTURE OF ACTH-ACTIVE AND ACTH-INACTIVE COMPONENTS OBTAINED FROM PITUITARY GLANDS, CHARACTERIZED BY THE STEPS OF PERCOLATING SAID MIXTURE IN AN AQUEOUS SOLUTION AT AN ALKALINE PH UP TO 9.0 THROUGH A FINELY-DIVIDED BED OF THE SALE FORM OF A CARBOXYLIC-TYPE CATION EXCHANGE RESIN, SAID RESIN BEING CHARACTERIZED BY HAVING CARBOXYLIC ACID GROUPS IN THE SALT FROM AS THE ONLY ACTIVE EXCHANGE CENTERS, THEREBY ADSORBING THE ACTH-INACTIVE COMPONENT ON SAID RESIN IN PREFERENCE TO SAID ACTH-INACTIVE COMPONENT, REMOVING A SUBSTANTIAL PORTION OF THE UNADSORBED ACTH-INACTIVE COMPONENT FROM SAID RESIN WITH THE PERCOLATE WHILE LEAVING THE ACTH-ACTIVE COMPONENT ON SAID RESIN, AND THEN ELUTING THE ACTH-ACTIVE COMPONENT FROM SAID RESIN BY PERCOLATING AN AQUEOUS SOLUTION AT AN ALKALINE PH ABOVE 8.0 THROUGH SAID RESIN, THEREBY OBTAINING IN THE PRECOLATE FROM SAID LAST-MENTIONED PERCOLATION AN ACTH PREPARATION OF ENHANCED POTENCY.
Claim 2
Dependent Claim
152 words
THE CHROMATOGRAPHIC SEPARATION METHOD FOR OBTAINING AN ADRENOCORTICOTROPIC HORMONE PREPARATION OF ENHANCED POTENCY FROM A MIXTURE OF ACTH-ACTIVE AND ACTH-INACTIVE COMPONENTS OBTAINED FROM PITUITARY GLANDS, CHARACTERIZED BY THE STEPS OF PERCOLATING SAID MIXTURE IN AN AQUEOUS SOLUTION AT AN ALKALINE PH UP TO 9.0 THROUGH A FINELY-DIVIDED BED OF THE SALE FORM OF A CARBOXYLIC-TYPE CATION EXCHANGE RESIN, SAID RESIN BEING CHARACTERIZED BY HAVING CARBOXYLIC ACID GROUPS IN THE SALT FROM AS THE ONLY ACTIVE EXCHANGE CENTERS, THEREBY ADSORBING THE ACTH-INACTIVE COMPONENT ON SAID RESIN IN PREFERENCE TO SAID ACTH-INACTIVE COMPONENT, REMOVING A SUBSTANTIAL PORTION OF THE UNADSORBED ACTH-INACTIVE COMPONENT FROM SAID RESIN WITH THE PERCOLATE WHILE LEAVING THE ACTH-ACTIVE COMPONENT ON SAID RESIN, AND THEN ELUTING THE ACTH-ACTIVE COMPONENT FROM SAID RESIN BY PERCOLATING AN AQUEOUS SOLUTION AT AN ALKALINE PH ABOVE 8.0 THROUGH SAID RESIN, THEREBY OBTAINING IN THE PRECOLATE FROM SAID LAST-MENTIONED PERCOLATION AN ACTH PREPARATION OF ENHANCED POTENCY.
References Cited (Backward Citations)
US2375979A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1963-07-19 | 1964-01-18 | 1964-07-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1967-07-19 | 1968-01-18 | 1968-07-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1971-07-19 | 1972-01-18 | 1972-07-19 | $7700.00 | Window Closed / Lapsed |