Preparation of crystalline oxytetracycline salts

Claim 1

A PROCESS FOR PREPARING AN OXYTETRACYLINE HYDROHALIDE SALT WHICH COMPRISES DISSOLVING UP TO ABOUT 0.3 G./ML. OF AMPHOTERIC OXYTETRACYCLINE, RECOVERED FROM A FERMENTATION BROTH AND CONTAINING LOWER ALKANOL INSOLUBLE IMPURITIES IN A LOWER ALKANOL IN THE PRESENCE OF A LOWER ALKANOL SOLUBLE SOLUBILIZING AGENT SELECTED FROM THE GROUP CONSISTING OF 0.01 TO 0.05 G./ML. OF AN ANHYDROUS HYDROGEN HALIDE, 0.01 TO 0.05 G./ML. OF CONCENTRATED HYDROHALIC ACID, 0.02 TO 0.3 G,/ML. OF A LOWER ALKANOL SOLUBLE ALKALI METAL HALIDE, 0.02 TO 0.3 G./ML. OF A LOWER ALKANOL SOLUBLE ALKALINE EARTH METAL HALIDE, AND 0.02 TO 0.3 G./ML.OF A LOWER ALKANOL SOLUBLE ZINC HALIDE, SEPARATING PRECIPITATED IMPURITIES AND SUBSEQUENTLY TREATING SAID SOLUTION WITH 0.02 TO 0.06G./ML OF A HYDROGEN HALIDE THEREBY PRECIPITATING SAID OXYTETRACYCLINE HYDROHALIDE SASLT.