US2881192A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of isolating and purifying keto steroids and new keto steroid compounds
Assignee: Laboratoires Francais de Chimiotherapie SA
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Filing: 1956-04-20
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Granted: 1959-04-07
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Expires: 1976-04-20
Abstract
No abstract record available.
Inventors
- 👤 Velluz Leon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 00:58
CPC Classifications
C; C07; C07J; C07J5/00; C07J75/00
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
35 words
THE 3-MONO-BENZILIC ACID HYDRAZONE OF A KETO STERIOD COMPOUND SELECTED FROM THE GROUP CONSISTING OF THE ESTER OF CORTISONE WITH A LOWER ALKANOIC ACID AND THE ESTER OF 3,11,20-TRIKETO-17A,21-DIHYDROXY PREGANE WITH A LOWER ALKANOIC ACID.
Claim 2
Dependent Claim
35 words
THE 3-MONO-BENZILIC ACID HYDRAZONE OF A KETO STERIOD COMPOUND SELECTED FROM THE GROUP CONSISTING OF THE ESTER OF CORTISONE WITH A LOWER ALKANOIC ACID AND THE ESTER OF 3,11,20-TRIKETO-17A,21-DIHYDROXY PREGANE WITH A LOWER ALKANOIC ACID.
Claim 3
Dependent Claim
114 words
IN A PROCESS OF PURIFYING AND ISOLATING CORTISONE ACETATE FROM 21-ACETATE OF 3,11,20-TRIKETO-17A,21-DIHYDROXY PREGANE, THE STEPS COMPRISING DISSOLVING SAID MIXTURE IN METHANOL CONTAINING ACETIC ACID, ADDING THERETO THE HYDRAZIDE OF BENZILIC ACID, BOILING THE REACTION MIXTURE UNDER REFLUX UNTIL CONDENSATION IS COMPLETED, COOLING THE REACTION MIXTURE, SEPARATING THE PRECIPITATED MIXTURE OF HYDRAZONES B, MIXING AND MODERATELY HEATING SAID MIXTURE WITH DICHLORO ETHANE AND REPEATING SAID MIXING AND MODERATELY HEATING OF THE UNDISSOLVED HYDRAZONES B WITH DICHLORO ETHANE UNTIL NO MORE HYDRAZONE IS DISSOLVED, SEPARATING THE UNDISSOLVED HYDRAZONE B OF 3,11,20-TRIKETO17A-HYDROXY-21-ACETOXY PREGANE FROM THE DICHLORO ETHANE SOLUTIONS, AND REMOVING THE SOLVENT FROM THE COMBINED DICHLORO ETHANE EXTRACTS, THEREBY YIELDING THE HYDRAZONE B OF CORTISONE ACETATE.
Claim 4
Dependent Claim
114 words
IN A PROCESS OF PURIFYING AND ISOLATING CORTISONE ACETATE FROM 21-ACETATE OF 3,11,20-TRIKETO-17A,21-DIHYDROXY PREGANE, THE STEPS COMPRISING DISSOLVING SAID MIXTURE IN METHANOL CONTAINING ACETIC ACID, ADDING THERETO THE HYDRAZIDE OF BENZILIC ACID, BOILING THE REACTION MIXTURE UNDER REFLUX UNTIL CONDENSATION IS COMPLETED, COOLING THE REACTION MIXTURE, SEPARATING THE PRECIPITATED MIXTURE OF HYDRAZONES B, MIXING AND MODERATELY HEATING SAID MIXTURE WITH DICHLORO ETHANE AND REPEATING SAID MIXING AND MODERATELY HEATING OF THE UNDISSOLVED HYDRAZONES B WITH DICHLORO ETHANE UNTIL NO MORE HYDRAZONE IS DISSOLVED, SEPARATING THE UNDISSOLVED HYDRAZONE B OF 3,11,20-TRIKETO17A-HYDROXY-21-ACETOXY PREGANE FROM THE DICHLORO ETHANE SOLUTIONS, AND REMOVING THE SOLVENT FROM THE COMBINED DICHLORO ETHANE EXTRACTS, THEREBY YIELDING THE HYDRAZONE B OF CORTISONE ACETATE.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1962-04-06 | 1962-10-06 | 1963-04-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1966-04-06 | 1966-10-06 | 1967-04-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1970-04-06 | 1970-10-06 | 1971-04-07 | $7700.00 | Window Closed / Lapsed |