Antibiotic purification and complex compounds

Claim 1

A PROCESS FOR THE RECOVERY OF OXYTETRACYCLINE FROM AN AQUEOUS SOLUTION THEREOF OBTAINED FROM A FERMENTATION BROTH, WHICH COMPRISES TREATING SAID AQUEOUS SOLUTION IN THE PRESENCE OF POLYVALENT METAL IONS AT A PH OF AT LEAST ABOUT 5.5 AND UP TO ABOUT 10 WITH AT LEAST AN EXCESS OF ONE ORGANIC BASE SELECTED FROM THE GROUP CONSISTING OF (A) PRIMARY ALKYL AMINES HAVING FROM 6 TO 12 CARBON ATOMS; (B) SECONDARY ALKYL AMINES WHEREIN TWO ALKYL GROUPS HAVING BETWEEN 6 AAND 9 CARBON ATOMS EACH ARE ATTACHED TO THE NITROGEN; (C) 1-SHORT CHAIN ALKYL-2-LONG CHAIN ALKYL IMIDAZOLINES WHEREIN THE SHORT CHAIN ALKYL GROUP HAS BETWEEN 1 AND 4 CARBON ATOMS; THE LONG CHAIN ALKYL HAS BETWEEN 7 AND 17 CARBON ATOMS; (D) 1-SHORT CHAIN HYDROXYALKYL-2-LONG CHAIN ALKYL IMIDAZOLINES WHEREIN THE SHORT CHAIN HYDROXYALKYL HAS BETWEEN 1 AND 4 CARBON ATOMS AND THE LONG CHAIN ALKYL HAS BETWEEN 7 AND 17 CARBON ATOMS; (E) PRIMARY PHENYLALKYL AMINES WHEREIN THE ALKYL GROUP HAS BETWEEN I AND 3 CARBON ATOMS; (F) LONG CHAIN SLKYL TRI-SHORT CHAIN ALKYL AMMONIUM HALIDES WHEREIN THE LONG CHAIN ALKYL HAS BETWEEN 8 AND 18 CARBON ATOMS AND THE SHORT CHAIN ALKYL HAS BETWEEN 1 AND 3 CARBON ATOMS AND THE HALIDE IS CHOSEN FROM THE GROUP CONSISTING OF CHLORIDE, BROMIDE, AND IODIDE; (G) LONG CHAIN ALKYL DI-SHORT CHAIN ALKYL BENZYL AMMONIUM HALDIES WHEREIN THE LONG CHAIN ALKYL GROUP HAS BETWEEN 8 AND 18 CARBON ATOMS, THE SHORT CHAIN ALKYL GROUP HAS BETWEEN 1 AND 3 CARBON ATOMS AND THE HALIDE IS CHOSEN FROM THE GROUP CONSISTING OF CHLORIDE, BROMIDE, AND IODIDE; (H) MEDIUM CHAIN ALKYL BENZYL TRI-SHORT CHAIN ALKYL AMMONIUM HALIDES WHEREIN THE MEDIUM CHAIN IS ATTACHED TO THE BENZYL GROUP AND HAS BETWEEN 4 AND 8 CARBON ATOMS AND THE SHORT CHAIN ALKYL GROUP HAS BETWEEN 1 AND 3 CARBON ATOMS; (I) DI-MEDIUM CHAIN ALKYL-DI-SHORT CHAIN CHAIN ALKYL AMMONIUM HALIDES WHEREIN THE MEDIUM CHAIN ALKYL GROUP HAS BETWEEN 6 AND 18 CARBON ATOMS AND THE SHORT CHAIN ALKYL GROUP HAS BETWEEN 1 AND 3 CARBON ATOMS AND THE HALIDE IS CHOSEN FROM THE GROUP CONSISTING OF BROMIDE, CHLORIDE AND IODIE; (J) 1-SHORT CHAIN ALKYTL-2-LONG CHAIN ALKYL-3-SHORT CHAIN ALKYL IMIDAZOLINIUM HALIDES WHEREIN THE SHORT CHAIN ALKYL GROUP HAS FROM 1 TO 4 CARBON ATOMS, THE LONG CHAIN ALKYL GROUP HAS FROM 7 TO 17 CARBON ATOMS, AND THE HALIDE IS CHOSEN FROM THE GROUP CONSISTING OF CHLORIDE, BROMIDE AND IODIDE; (K) 1-SHORT CHAIN AALKYL-2-LONG CHAIN ALKYL-3-BENZYL IMIDAZOLINIUM HALIDES WHEREIN THE SHORT CHAIN ALKYL GROUP HAS FROM 1 TO 4 CARBON ATOMS AND THE LONG CHAIN ALKYL GROUP HAS FROM 7 TO 17 CARBON ATOMS; (L) 1-SHORT CHAIN HYDROXYALKYL-2-LONG CHAIN ALKYL-3-SHORT CHAIN ALKYL IMIDAZOLINIUM HALIDES WHEREIN THE SHORT CHAIN HYDROXYALKYL GROUPS HAVE FROM 1 TO 4 CARBON ATOMS, THE LONG CHAIN ALKYL GROUP HAS FROM 7 TO 17 CARBONS ATOMS. AND THE HALIDE IS CHOSEN FROM THE GROUP CONSISTING OF CHLORIDE, BROMIDE, AND IODIDE; (M) (MEDIUM CHAIN ALKYL) PHENOXYETHOXYETHYL DI-SHORT CHAIN ALKYLBENZYLAMMONUUM HALIDES WHEREIN THE MEDIUM CHAIN ALKYL GROUP HAS FROM 6 TO 12 CARBON ATOMS, THE SHORT CHAIN ALKYLS HAVE BETWEEN 1 AND 3 CARBON ATOMS EACH, AND THE HALIDE IS CHOSEN FROM THE GROUP CONSISTING OF CHLORIDE, BROMIDE, AND IODIDE; (N) N,N''-DI-((MEDIUM CHAIN ALKYLBENZYL) DIMETHYL AMMONIUM ACETYL) ETHYLENEDIAMINE DIHALIDES WHEREIN THE MEDIUM CHAIN ALKYL GROUP HAS FROM 6 TO 12 CARBON ATOMS AND THE HALIDE IS CHOSEN FROM THE GROUP CONSISTING OF CHLORIDE, BROMIDE, AND IODIDE; (O) N-(LONG CHAIN ALKANOYL ETHANOLAMINOFORMYLMETHYL) PYRIDINIUM HALIDES WHEREIN THE LONG CHAIN ALKANOYL GROUP HAS FROM 8 TO 18 CARBON ATOMS AND THE HALIDE IS CHOSEN FROM THE GROUP CONSISTING OF CHLORIDE, BROMIDE AND IODIDE; AND RECOVERING THE METAL ION-ORGANIC BASE-OXYTETRACYCLINE ANTIBIOTIC COMPLEX THEREBY PRECIPITATED.