US2790814A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Steroid production
Assignee: Pharmacia and Upjohn Co
•
Filing: 1953-04-01
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Granted: 1957-04-30
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Expires: 1973-04-01
Abstract
No abstract record available.
Inventors
- 👤 John A Hogg
- 👤 Iii Philip F Beal
- 👤 Alan H Nathan
- 👤 Jr Frank H Lincoln
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 00:59
CPC Classifications
C; C07; C07J; C07J13/00; C07J75/00
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
215 words
A PROCESS WHICH INCLUDES THE STEPS OF (1) MIXING A $4-3-KETO COMPOUND HAVING AN ANDROSTANE CARBON SKELETON AND HAVING AT THE 17 POSITION A HYDROGEN ATOM AND AN ACETYL GROUP, AND HAVING TWO HYDROGEN ATOMS AT THE 2 POSITION OF THE STEROID NUCLEUS, WITH AT LEAST ABOUT TWO MOLAR EQUIVALENTS EACH OF AN ALKALI-METAL BASES CONDENSING AGENT AND AN ALKYL DIESTER OF OXALIC ACID TO PRODUCE A STEROID CONDENSATION PRODUCT WHICH INCLUDES A $4 -3,20 - DIKETO - 2,21 - DIALKOXYOXALYL ALKALI-METAL DIENOLATE COMPOUND OF THE PREGNANE SERIES; AND (2) REACTING TAHE THUS-PRODUCED STERIOD CONDENSATION PRODUCT WITH AT LEAST ABOUT TWO MOLAR EQUIVALENTS OF A HALOGEN HAVING AN ATOMIC WEIGHT FROM 35 TO 80, BUT NOT SUBSTANTIALLY EXCEEDING THAT AMOUNT REQUIRED TO MAINTAIN FREE HALOGEN IN THE REACTION MIXTURE, TO PRODUCE A HALOGENATION PRODUCT WHICH INCLUDES A $4 3,20 - DIKETA - 2,21,21 TRIHALO- 2,21 - DIALKOXYOXALYL COMPOUND OF THE PREGNANE SERIES; AND (3) REACTING THE THUS-PRODUCED STEROID HALOGENATION PRODUCT WITH AT LEAST TWO MOLAR EQUIVALENTS EACH OF AN ALKANOL AND ABASE TO PRODUCE A STEROID REACTION PRODUCT WHICH INCLUDES A $4,17(20)-2-HALO-3-KETO-21-OIC ACID ALKYL ESTER COMPOUND OF THE REPNANE SERIES; AND (4) RAEACTING TAHE THUS-PRODUCED 2-HALOGENATED STEROID ACID ESTER WITH A DEHALOGENATING AGENT TO PRODUCE A $4,17(20)3-KETO-21-OIC ACID ALKYL ESTER COMPOUND OF THE PREGNANE SERIES.
Claim 2
Dependent Claim
215 words
A PROCESS WHICH INCLUDES THE STEPS OF (1) MIXING A $4-3-KETO COMPOUND HAVING AN ANDROSTANE CARBON SKELETON AND HAVING AT THE 17 POSITION A HYDROGEN ATOM AND AN ACETYL GROUP, AND HAVING TWO HYDROGEN ATOMS AT THE 2 POSITION OF THE STEROID NUCLEUS, WITH AT LEAST ABOUT TWO MOLAR EQUIVALENTS EACH OF AN ALKALI-METAL BASES CONDENSING AGENT AND AN ALKYL DIESTER OF OXALIC ACID TO PRODUCE A STEROID CONDENSATION PRODUCT WHICH INCLUDES A $4 -3,20 - DIKETO - 2,21 - DIALKOXYOXALYL ALKALI-METAL DIENOLATE COMPOUND OF THE PREGNANE SERIES; AND (2) REACTING TAHE THUS-PRODUCED STERIOD CONDENSATION PRODUCT WITH AT LEAST ABOUT TWO MOLAR EQUIVALENTS OF A HALOGEN HAVING AN ATOMIC WEIGHT FROM 35 TO 80, BUT NOT SUBSTANTIALLY EXCEEDING THAT AMOUNT REQUIRED TO MAINTAIN FREE HALOGEN IN THE REACTION MIXTURE, TO PRODUCE A HALOGENATION PRODUCT WHICH INCLUDES A $4 3,20 - DIKETA - 2,21,21 TRIHALO- 2,21 - DIALKOXYOXALYL COMPOUND OF THE PREGNANE SERIES; AND (3) REACTING THE THUS-PRODUCED STEROID HALOGENATION PRODUCT WITH AT LEAST TWO MOLAR EQUIVALENTS EACH OF AN ALKANOL AND ABASE TO PRODUCE A STEROID REACTION PRODUCT WHICH INCLUDES A $4,17(20)-2-HALO-3-KETO-21-OIC ACID ALKYL ESTER COMPOUND OF THE REPNANE SERIES; AND (4) RAEACTING TAHE THUS-PRODUCED 2-HALOGENATED STEROID ACID ESTER WITH A DEHALOGENATING AGENT TO PRODUCE A $4,17(20)3-KETO-21-OIC ACID ALKYL ESTER COMPOUND OF THE PREGNANE SERIES.
References Cited (Backward Citations)
US2683724A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1960-04-29 | 1960-10-29 | 1961-04-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1964-04-29 | 1964-10-29 | 1965-04-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1968-04-29 | 1968-10-29 | 1969-04-30 | $7700.00 | Window Closed / Lapsed |