US2769810A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for preparing hydroxy-n-methylmorphinan
Assignee: Shionogi and Co Ltd
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Filing: 1955-07-13
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Granted: 1956-11-06
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Expires: 1975-07-13
Abstract
No abstract record available.
Inventors
- 👤 Ochiai Eiji
- 👤 Ikehara Morio
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 19:05
CPC Classifications
C; C07; C07D; C07D217/00; C07D217/12; C07D217/18; C07D217/20; C07D221/00; C07D221/02; C07D221/22; C07D221/28
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
104 words
A PROCESS FOR PREPARING HYDROXY-N-METHYLMORPHINAN WHICH COMPRISES CONDENSING 1-CHLORO-5,6,7,8-TETRAHYDROISOQUINOLINE WITH LOWER ALKOXYBENZYL CYANIDE WHICH HAS NO ALKOXY RADICAL AT LEAST ONE SIDE OF THE ORTHO POSITIONS IN THE PRESENCE OF A CONDENSING AGENT SELECTED FROM THE GROUP CONSISTING OF ALKALI METAL AMIDE AND ALKALINE EARTH METAL AMIDE, REACTING 1-(A-CARBAMOYL)ALKOXYBENZYL-5,6,7,8-TETRAHYDROISOQUINOLINE OBTAINED BY THE HYDROLYSIS OF THE RESULTING 1-(A-CYANO)ALKOXYBENZYL-5,6,7,8TETRACHYDROISOQUINOLINE WITH METHYL IODIDE TO METHIODIDE THEREOF, REDUCING THE METHIODIDE BY MEANS OF PLATINUM CATALYST TO 1-(A-CARBAMOYL-ALKOXYBENZYL - N- METHYL1,2,3,4,5,6,7,8-OCTAHYDROISOQUINOLINE, AND THEN TREATING THE LATTER WITH A STRONG ACIDIC CONDENSING AGENT SELECTED FROM THE GROUP CONSISTING OF CONCENTRATED PHOSPHORIC ACID AND CONCENTRATED HYDROHALOGENIC ACID TO PRODUCE THE OBJECT.
Claim 2
Dependent Claim
104 words
A PROCESS FOR PREPARING HYDROXY-N-METHYLMORPHINAN WHICH COMPRISES CONDENSING 1-CHLORO-5,6,7,8-TETRAHYDROISOQUINOLINE WITH LOWER ALKOXYBENZYL CYANIDE WHICH HAS NO ALKOXY RADICAL AT LEAST ONE SIDE OF THE ORTHO POSITIONS IN THE PRESENCE OF A CONDENSING AGENT SELECTED FROM THE GROUP CONSISTING OF ALKALI METAL AMIDE AND ALKALINE EARTH METAL AMIDE, REACTING 1-(A-CARBAMOYL)ALKOXYBENZYL-5,6,7,8-TETRAHYDROISOQUINOLINE OBTAINED BY THE HYDROLYSIS OF THE RESULTING 1-(A-CYANO)ALKOXYBENZYL-5,6,7,8TETRACHYDROISOQUINOLINE WITH METHYL IODIDE TO METHIODIDE THEREOF, REDUCING THE METHIODIDE BY MEANS OF PLATINUM CATALYST TO 1-(A-CARBAMOYL-ALKOXYBENZYL - N- METHYL1,2,3,4,5,6,7,8-OCTAHYDROISOQUINOLINE, AND THEN TREATING THE LATTER WITH A STRONG ACIDIC CONDENSING AGENT SELECTED FROM THE GROUP CONSISTING OF CONCENTRATED PHOSPHORIC ACID AND CONCENTRATED HYDROHALOGENIC ACID TO PRODUCE THE OBJECT.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1959-11-06 | 1960-05-07 | 1960-11-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1963-11-06 | 1964-05-07 | 1964-11-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1967-11-06 | 1968-05-07 | 1968-11-06 | $7700.00 | Window Closed / Lapsed |