US2651634A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for the preparation of 1-benzyl-5, 6, 7, 8-tetrahydroisoquinoline
Assignee: Bayer AG
•
Filing: 1950-12-09
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Granted: 1953-09-08
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Expires: 1970-12-09
Abstract
No abstract record available.
Inventors
- 👤 Henecka Hans
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 11:04
CPC Classifications
C; C07; C07D; C07D217/00; C07D217/02; C07D217/22; C07D217/24; C07D217/26
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
80 words
PROCESS FOR THE SYNTHESIS OF INTERMEDIATES FOR THE MANUFACTURE OF THERAPEUTIC AGENTS THAT COMPRISES CONDENSING A PHENYLACETIC ESTER WITH CYCLOHEXANONE TO PRODUCE 2-(A-TOLUYL) -CYCLOHEXANONE, REACTING THIS PRODUCT WITH CYANACETAMIDE TO FORM 1-BENZYL-2,3,5,6,7,8-HEXAHYDRO-4-CYANOISOQUINOLONE-3, SUBJECTING THIS PRODUCT TO HYDROLYSIS UNDER MILDLY ACIDIC CONDITIONS TO EFFECT REMOVAL OF THE SUBSTITUENT CYANO GROUP, REACTING THE PRODUCT WITH A PHOSPHORUS OXYHALIDE TO REPLACE THE SUBSTITUENT 3-KETO GROUP WITH A HALOGEN SUBSTITUENT, REDUCING THIS HALOGEN COMPOUND BY CATALYTIC HYDROGENATION AND RECOVERING 1-BENZYL5,6,7,8-TETRAHYDROISOQUINOLINE FROM THE REACTION MIXTURE.
Claim 2
Dependent Claim
80 words
PROCESS FOR THE SYNTHESIS OF INTERMEDIATES FOR THE MANUFACTURE OF THERAPEUTIC AGENTS THAT COMPRISES CONDENSING A PHENYLACETIC ESTER WITH CYCLOHEXANONE TO PRODUCE 2-(A-TOLUYL) -CYCLOHEXANONE, REACTING THIS PRODUCT WITH CYANACETAMIDE TO FORM 1-BENZYL-2,3,5,6,7,8-HEXAHYDRO-4-CYANOISOQUINOLONE-3, SUBJECTING THIS PRODUCT TO HYDROLYSIS UNDER MILDLY ACIDIC CONDITIONS TO EFFECT REMOVAL OF THE SUBSTITUENT CYANO GROUP, REACTING THE PRODUCT WITH A PHOSPHORUS OXYHALIDE TO REPLACE THE SUBSTITUENT 3-KETO GROUP WITH A HALOGEN SUBSTITUENT, REDUCING THIS HALOGEN COMPOUND BY CATALYTIC HYDROGENATION AND RECOVERING 1-BENZYL5,6,7,8-TETRAHYDROISOQUINOLINE FROM THE REACTION MIXTURE.
References Cited (Backward Citations)
CH253710A
Cited
US2554842A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1956-09-07 | 1957-03-09 | 1957-09-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1960-09-07 | 1961-03-09 | 1961-09-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1964-09-07 | 1965-03-09 | 1965-09-08 | $7700.00 | Window Closed / Lapsed |