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US2624691A Expired / Lapsed US ⏱️ 0.0 years remaining

Fibrinolysin derived from blood and methods of obtaining the same

Assignee: Parke Davis and Co LLC
•
Filing: 1946-04-22
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Granted: 1953-01-06
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Expires: 1966-04-22
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Abstract

No abstract record available.

Inventors

  • 👤 Eugene C Loomis

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-30 08:54
CPC Classifications
C; C12; C12N; C12N9/00; C12N9/14; C12N9/48; C12N9/50; C12N9/64; C12N9/6421; C12N9/6424; C12N9/6435; C12Y; C12Y304/00; C12Y304/21; C12Y304/21007; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S435/00; Y10S435/814; Y10S435/816

Claims Analysis

Total Claims: 4
Claim 1
Independent Claim 142 words
METHOD FOR OBTAINING PROFIBRINOLYSIN WHICH COMPRISES TREATING SERUM OF THE CLASS MAMMALIAN BLOOD SERUM AND MAMMALIAN BLOOD SERUM CONTAINING THROMBOPLASTIN AND FIBRINOGEN BUT NO PROTHROMBIN, WITH A PROTEIN PRECIPITATING WATER SOLUBLE SULFATE SALT, AT TEMPERATURES ABOVE FREEZING FOR SAID SERUM AND BELOW THAT CAUSING PROTEIN DENATURATION, AT A MAXIMUM CONCENTRATION OF SAID SALT FOR PRECIPITATING PROTEIN ABOVE THAT CORRESPONDING TO ABOUT 20 PERCENT OF SATURATION WITH AMMONIUM SULFATE AND BELOW THAT CORRESPONDING TO ABOUT 35 PERCENT OF SATURATION WITH AMMONIUM SULFATE NOT CAUSING SUBSTANTIAL PRECIPITATION OF PROFIBRINOLYSIN CONTAINED THEREIN, REMOVING THE SOLUTION CONTAINING PROFIBRINOLYSIN FROM PRECIPITATED PROTEINS, INCREASING THE CONCENTRATION OF SAID WATER SOLUBLE SULFATE SALT IN THE SOLUTION CONTAINING PROFIBRINOLYSIN TO A DEGREE OPTIMAL FOR PRECIPITATION OF PROFIBRINOLYSIN WITH MINIMUM PRECIPITATION OF IMPURITIES AND WITHIN THE ABOVE LIMITS OF CORRESPONDING AMMONIUM SULFATE SATURATION, AND SEPARATING THE PRECIPITATED PROFIBRINOLYSIN FROM THE SOLUTION.
Claim 2
Dependent Claim 142 words
METHOD FOR OBTAINING PROFIBRINOLYSIN WHICH COMPRISES TREATING SERUM OF THE CLASS MAMMALIAN BLOOD SERUM AND MAMMALIAN BLOOD SERUM CONTAINING THROMBOPLASTIN AND FIBRINOGEN BUT NO PROTHROMBIN, WITH A PROTEIN PRECIPITATING WATER SOLUBLE SULFATE SALT, AT TEMPERATURES ABOVE FREEZING FOR SAID SERUM AND BELOW THAT CAUSING PROTEIN DENATURATION, AT A MAXIMUM CONCENTRATION OF SAID SALT FOR PRECIPITATING PROTEIN ABOVE THAT CORRESPONDING TO ABOUT 20 PERCENT OF SATURATION WITH AMMONIUM SULFATE AND BELOW THAT CORRESPONDING TO ABOUT 35 PERCENT OF SATURATION WITH AMMONIUM SULFATE NOT CAUSING SUBSTANTIAL PRECIPITATION OF PROFIBRINOLYSIN CONTAINED THEREIN, REMOVING THE SOLUTION CONTAINING PROFIBRINOLYSIN FROM PRECIPITATED PROTEINS, INCREASING THE CONCENTRATION OF SAID WATER SOLUBLE SULFATE SALT IN THE SOLUTION CONTAINING PROFIBRINOLYSIN TO A DEGREE OPTIMAL FOR PRECIPITATION OF PROFIBRINOLYSIN WITH MINIMUM PRECIPITATION OF IMPURITIES AND WITHIN THE ABOVE LIMITS OF CORRESPONDING AMMONIUM SULFATE SATURATION, AND SEPARATING THE PRECIPITATED PROFIBRINOLYSIN FROM THE SOLUTION.
Claim 3
Dependent Claim 86 words
FIBRINOLYSIN DERIVED FROM MAMMALIAN BLOOD SAID FIBRINOLYSIN HAVING A POTENCY OF 5 TO 30 UNITS PER MILLIGRAM OF NITROGEN; BEING SOLUBLE IN WATER AND SALINE, FREE FROM PROTHROMBIN, THROMBIN, THROMBOPLASTIN, FIBRINOGEN AND FIBRIN; INCAPABLE OF CLOTTING FIBRINOGEN; INCAPABLE OF CONVERTING PROTHROMBIN TO THROMBIN; NOT INHIBITED BY PROTHROMBIN; CAPABLE OF DESTROYING PROTHROMBIN, FIBRINOGEN AND FIBRIN; AND SAID FIBRINOLYSIN IN AQUEOUS SOLUTION REMAINING IN SOLUTION WITHOUT CLOT FORMATION WHEN TREATED WITH ANY ONE PRODUCT OF THE CLASS CONSISTING OF THROMBIN, FIBRINOGEN, AND A COMBINATION OF FIBRINOGEN AND THROMBOPLASTIN.
Claim 4
Dependent Claim 86 words
FIBRINOLYSIN DERIVED FROM MAMMALIAN BLOOD SAID FIBRINOLYSIN HAVING A POTENCY OF 5 TO 30 UNITS PER MILLIGRAM OF NITROGEN; BEING SOLUBLE IN WATER AND SALINE, FREE FROM PROTHROMBIN, THROMBIN, THROMBOPLASTIN, FIBRINOGEN AND FIBRIN; INCAPABLE OF CLOTTING FIBRINOGEN; INCAPABLE OF CONVERTING PROTHROMBIN TO THROMBIN; NOT INHIBITED BY PROTHROMBIN; CAPABLE OF DESTROYING PROTHROMBIN, FIBRINOGEN AND FIBRIN; AND SAID FIBRINOLYSIN IN AQUEOUS SOLUTION REMAINING IN SOLUTION WITHOUT CLOT FORMATION WHEN TREATED WITH ANY ONE PRODUCT OF THE CLASS CONSISTING OF THROMBIN, FIBRINOGEN, AND A COMBINATION OF FIBRINOGEN AND THROMBOPLASTIN.

References Cited (Backward Citations)

US2394566A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1956-01-06 1956-07-07 1957-01-06 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1960-01-06 1960-07-07 1961-01-06 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1964-01-06 1964-07-07 1965-01-06 $7700.00 Window Closed / Lapsed

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