Porphycene Compounds for Photodynamic Therapy

Abstract

Abstract A porphycene having the structure <IMAGE> wherein each R1 is, independently, (a) -(CH2)n-X, where n=1-4, X is OR2 and R2 is C1-6 alkyl, aralkyl or aryl; CN; OH; OSO2R2; NH2; NHR2; NR22; SH; SR2; S(O)1-2R2; COOH; CO2R2; C(O)NH2; C(O)NHR2; C(O)NR22; halogen; or CHO; (b) -(CH2)mCH=CH2 where m is 0-2; or (c) -(CH2)n-O-G where G is a mono- or oligosaccharide; (d) -(CH2)2n-X, where X is an amino acid, oligopeptide covalently bonded by an ether-, ester- or amine-bond or -Y-(CH2)n-porphycene2 (porphycene2 being a compound of the same structure and Y is a direct bond; -O-; or -CH=CH2); or (e) where one, two or three of the substituents R1 are C1-6 alkyl or aryl and the remaining substituents are as above under (a)-(d), and salts and metal complexes thereof. The porphycene compounds and pharmaceutical compositions containing the compounds are useful in photodynamic therapy treatment of tumors and psoriasis.

Inventors

• 👤 Emanuel Vogel
• 👤 Thomas Benninghaus
• 👤 Clemens Richert
• 👤 Martin Muller
• 👤 Alexander Dennis Cross

Bibliographic Details