Novel cephalosporin derivative

Abstract

Abstract NEW MATERIAL:A compound expressed by formula I (R represents vinyl, phenyl or aralkyl which may have a substituent group), salt or hydrolyzable ester thereof. EXAMPLE: 7-[2-(2-Aminothiazol-4-yl)-2-(1-carboxy-1-vinyloxyimino)acetamide]-3-(1- carboxymethylpyridinio-4-yl)thiomethyl-4-carboxylate. USE: An antibacterial agent, especially useful for treating human microbisms with Gram-negative bacteria containing especially glucose-nonfermenting Gram- negative bacilli as prophlogstic bacteria. PREPARATION: A compound (salt) expressed by formula II (R 1 is same as R; R 2 represents H or carboxyl-protecting group; R 3 represents H or amino- protecting group; X represents leaving group) is reacted with a compound expressed by formula III (R 4 is same as R 2 ) to form a compound expressed by formula IV, as necessary, followed by elimination of protecting groups. COPYRIGHT: (C)1989,JPO&Japio

Inventors

• 👤 Susumu Nakagawa
• 👤 Takashi Mitomo
• 👤 Ryosuke Ushijima

Bibliographic Details