H2-receptor antagonist compound

Abstract

Abstract NEW MATERIAL: Compd. expressed by formula I or its O-alkylidene, 5,6-diacyl, 6-acyl derivs. (with 2 to 16 carbon atoms) or 6-phosphate. In formula I, X is 1 to 3; Y is 1 or 2; R 1 , R 2 are each H, or R 1 is OH, and R 2 is H; Z is H, alkali (earth) metal; R 3 is a functional org. base having one or more basic groups and having H 2 -receptor antagonist characteristics, and R3 may be salt with one mol of aspartic acid, glutamic acid, caffeic acid, ferulic acid or gallic acid. EXAMPLE: N"-cyano-N'-methyl-N-2-(5-methyl-1H-imidazol-4-yl) methylthioethylguanidine [cimetidine]. USE: H 2 -receptor antagonist and drug for gastrointestinal and duodenal disorders. PROCESS: A 3-ketohexuronic acid (derivative) expressed by formula II is allowed to react with an org. base (salt) expressed by R 3 in an inert org. solvent at room temp. to the solvent refluxing temp. COPYRIGHT: (C)1989,JPO

Inventors

• 👤 Rodes Montserrat Ballester
• 👤 Francisco Eugenio Palomo-Nicolau
• 👤 Oller Jose Maria Solis
• 👤 Coll Antonio Luis Palomo

Bibliographic Details