2-amino-alpha-phenylphenethylamine

Abstract

Abstract NEW MATERIAL: A compd. of formula I [where R 1 is H, 1-3C alkyl, 3-6C cycloalkyl-1-3C alkyl or ≤8C aralkyl; each of X and Y is Cl, Br, F, 1-3C alkoxy, 1-3C alkyl, OH or CF 3 ; (m) is O-2 and (n) is 0-3]. EXAMPLE: N-acetyl-2-amino-α-(3,4-dimethoxyphenyl)-N-methylphenethylamine. USE: An intermediate for preparing phenyl-1,3-benzodiazepine useful as an antidepressant, an analgesic and an antispasmodic. PROCESS: The compd. of the formula I (where R 1 is H) is obtd. by converting 2-(2-nitrophenyl)acetophenone of formula II into oxime of formula III, acylating the oxime with acetic anhydride, carefully reducing the resultant oxime acetate of formula IV with diborane as a reducing agent and further reducing the resultant 2-nitro-α-phenylphenethylamine of formula V. COPYRIGHT: (C)1989,JPO

Inventors

• 👤 Lawrence L Martin
• 👤 Manfred Worm
• 👤 Charles A Crichlow

Bibliographic Details