Production of 4-hydroxy-2-cyclopentenone derivative

Abstract

Abstract PURPOSE: To obtain the titled compound useful as an intermediate for medicines, agricultural chemicals, etc., especially prostaglandin, by subjecting a 3-hydroxy-4- cyclopentenone derivative to isomerization treatment in the presence of chloral and an organic amine. CONSTITUTION: A compound expressed by formula I [X is CH 2 OH or COOR (R is H or 1W6C alkyl); n is 4W8] is subjected to isomerization treatment in the presence of chloral in a molar amount of 0.005W1, preferably 0.01W0.3 based on the above-mentioned compound and an organic amine (e.g. triethylamine or N-methylpiperidine) in a molar amount of 0.005W0.5 based on the afore-mentioned compound at -10W+100°C, preferably 0W+90°C temperature to afford the aimed compound expressed by formula II. COPYRIGHT: (C)1989,JPO&Japio

Inventors

• 👤 Takayuki Azumai
• 👤 Yuji Ueda
• 👤 Tomomasa Kondo
• 👤 Seiichi Kai
• 👤 Masayoshi Minamii

Bibliographic Details