Production of benzoylurea compound

Abstract

Abstract PURPOSE:To obtain the titled compound useful as a remedy for cancers, by reacting a 2-substituted benzoyl isocyanate with an aniline compound as 3- chloro-4-(5-trifluoromethyl-2-pyridyloxy)aniline, etc. CONSTITUTION:A compound (e.g., 2-chlorobenzoyl isocyanate, etc.) shown by the formula I (X is halogen, nitro or trifluoromethyl) is reacted with a compound shown by the formula II (Y and Z<2> are H or halogen; Z<1> is halogen or trifluoromethyl; A is =CH- or =N-) in the presence of a solvent such as ben zene, toluene, pyridine, etc., at 0-120 deg.C to give a benzoylurea compound [e.g., N-( 2-chlorobenzoyl )-N'-[3-chloro-4-(5-trifluoromethyl-2-pyridyloxy)phenyl]urea, etc.,] shown by the formula III.

Inventors

• 👤 Ryuzo Nishiyama
• 👤 西山　隆三
• 👤 Hiroyuki Mori
• 👤 森　拡之
• 👤 Yasuo Ogawa
• 👤 小川　康夫
• 👤 Takahiro Haga
• 👤 隆弘 芳賀
• 👤 Kuniaki Hase
• 👤 長谷　邦昭
• 👤 Noboru Fujikawa
• 👤 藤川　昇

Bibliographic Details