Crown compound

Abstract

Abstract NEW MATERIAL:An optically active crown compound shown by formula I {Ar is optically active bifunctional aromatic group, preferably [1,1'- binaphthyl]-2,2'-diyl or [3,3-diphenyl-1,1'-binaphthyl]-2,2'-diyl; R is 6-16C alkyl}. USE:An optically resolving agent having improved optically resolving ability and extremely small partition ratio to water phase. PREPARATION:A compound shown by formula II (M is alkyl metal) is reacted with an approximately equimolar amount of a compound shown by formula III (X is Cl, I or tosyloxy) in an inert gas atmosphere in an organic solvent such as tetrahydrofuran, dioxane, N, N'-dimethylformamide, etc., to give a compound shown by formula I. The compound can optically resolve amino acids or compounds such as amine, etc., by applying solvent extraction, immersion type liquid membrane, column for optical resolution, etc., and contributes to food industries and pharmaceutical business world of drugs, agricultural chemicals, etc.

Inventors

• 👤 Koichiro Nishimura
• 👤 浩一郎 西村
• 👤 Tomohiko Yamaguchi
• 👤 智彦 山口
• 👤 Toshio Shinpo
• 👤 外志夫 新保
• 👤 Masaaki Sugiura
• 👤 正昭 杉浦

Bibliographic Details