Production of crystal grain of hydroxyapatite for chromatography

Abstract

Abstract PURPOSE:To mass produce the titled crystal grain having uniform size and shape, simply, efficiently and at low cost, by subjecting water suspension of brushite crystal grain to dehydrating phase transition under heating in a specific temperature range to give monetite crystal grain and treating the monetite crystal grain with an alkali. CONSTITUTION:Brushite crystal grain shown by formula I which is relatively large-sized lamellar scaly crystal having 1-3mu thickness and tens mu average particle diameter is suspended in water and this water suspension is heated to a temperature range of dehydrating phase transition temperature - the boiling point of the water suspension and subjected to dehydrating phase transition to give monetite crystal grain (CaHPO4). Then an alkali (e.g. NaOH) is added to the monetite crystal grain, which is heated while stirring to give the titled crystal grain shown by formula II having improved separating ability as a stationary phase agent to be packed into a column for column chromatography.

Inventors

• 👤 Tsutomu Kawasaki
• 👤 力 川崎
• 👤 Wataru Kobayashi
• 👤 亘 小林

Bibliographic Details