Novel 7,7-dimethyl-2,3-epoxy-11-methylenespiro(5,5)undeca-3-carbaldehyde, preparation thereof and ameliorant for hepatic disorder containing said compound as active constituent

Abstract

Abstract NEW MATERIAL:A compound expressed by formula I. USE:An ameliorant for hepatic disorder. PREPARATION:7,7-Dimethyl-11-methylenespiro[ 5,5 ]undeca-2-ene-3-carbaldehyde expressed by formula II is reacted with hydrogen peroxide in a solvent under alkaline conditions to give the aimed compound expressed by formula I. The compound expressed by formula II is obtained by extracting a schisandra fruit with an organic solvent, e.g. petroleum ether, and subjecting the resultant extract to silica gel chromatography, high-speed liquid chromatography, etc.

Inventors

• 👤 Hiroshi Hikino
• 👤 曳野　宏
• 👤 Kunio Hosaka
• 👤 穂坂　邦男
• 👤 Yoshimitsu Ogawa
• 👤 義光 小川
• 👤 Yukinobu Iketani
• 👤 幸信 池谷
• 👤 Kiyoshi Kubota
• 👤 久保田　潔
• 👤 Heihachiro Taguchi
• 👤 平八郎 田口

Bibliographic Details