Alkylthioglucoside derivative

Abstract

Abstract NEW MATERIAL:The compound of formula I (R is 6-10C alkyl). EXAMPLE:n-Octylthioglucoside. USE:Solubilizing agent for biological substance. It can be produced at a low cost, and can be reconstituted to an artificial membrane. PREPARATION:For example, the acetyl-protected glucosethiourea compound of formula II is made to react with the compound of formula RX (X is halogen) (e.g. n-octyl bromide) e.g. in a 1:1 mixture of acetone and water, in the presence of potassium carbonate and sodium sulfite, etc. for 15hr under stirring, extracting the reaction product with methylene chloride, etc., and eliminating the protecting group by hydrolyzing with an alkali.

Inventors

• 👤 Sadao Saito
• 👤 斉藤　節生
• 👤 Tomofusa Tsuchiya
• 👤 友房 土屋

Bibliographic Details