Quinolonecarboxylic acid derivative

Abstract

Abstract NEW MATERIAL:A compound expressed by formula I (R is H, methyl or p-aminobenzyl; Y is Cl, F or methyl) and a hydrate and salt thereof. EXAMPLE:1-Cyclopropyl-6, 8-difluoro-7-( 1-piperazinyl )-4-oxoquinoline-3-carboxylic acid. USE:An antimicrobial agent, effective against Gram-negative and Gram-positive bacteria, and having characteristics of easy absorption and a lower alkyl group or p-aminobenzyl group bonded to the piperazine or a halogen group introduced into the 8-position. PREPARATION:A novel compound expressed by formula II (R<1> is H or alkyl; X is halogen) is condensed with a compound expressed by formula III (R<2> is H, p-nitrobenzyl or p-aminobenzyl), and the resultant condensate is hydrolyzed when R<1> is an alkyl group or further reduced when R<2> is p-nitrobenzyl to afford the aimed compound expressed by formula I .

Inventors

• 👤 Tsutomu Irikura
• 👤 勉 入倉
• 👤 Seigo Suzue
• 👤 清吾 鈴江
• 👤 Satoru Murayama
• 👤 哲 村山
• 👤 Keiji Hirai
• 👤 敬二 平井
• 👤 Takayoshi Ishizaki
• 👤 孝義 石崎

Bibliographic Details