Polynucleotide complex

Abstract

Abstract NEW MATERIAL:The poly( I ).poly( C)-poly-L-lysine-carboxymethylcellulose complex having an etherfication degree of carboxymethylcellulose of >=1.0. USE:It has high interferon-inducing activity and is useful as an antiviral agent and carcinostatic agent. PROCESS:The complex can be prepared by adding a poly-L-lysine (preferably having a molecular weight of 3,000-200,000) to a CMC solution having an etherification degree of >=1.0, preferably 1.2-1.45, adding a solution of poly(I).poly(C) [preferably the ratio of poly(I):poly(C) is 0.5-2, the concentration is 0.5-2mg/ ml, and the molecular size is 4-12S] slowly to the mixture under stirring, and continuing the agitation until the mixture becomes a homogeneous solution.

Inventors

• 👤 Haruhiko Machida
• 👤 治彦 町田
• 👤 Hiroshi Yamauchi
• 👤 寛 山内

Bibliographic Details