Stable cleatine amidinohydrolase pharmaceutical

Abstract

Abstract PURPOSE:A stable cleatine amidinohydrolase pharmaceutical containing a nonionic surfactant, etc. having >=14 hydrophilic-lipophilic balance (HLB) as a stabilizer without causing the deterioration nor clouding even in preservation in the form of a solution. CONSTITUTION:A cleatine amidinohydrolase pharmaceutical containing within 0.01-1,000mg range based on 100 units cleatine amidinohydrolase one or more stabilizers selected from the group consisting of a nonionic surfactant, e.g. polyoxyethylene alkyl phenyl ether or polyoxyethylene acyl ester, having >=14 hydrophilic-lipophilic balance (HLB) a chelating agent, e.g. ethylenediaminetetraacetic acid, and a preservative, e.g. azide, antibiotic substance and sulfamide agent therein.

Inventors

• 👤 Sachiko Yamaguchi
• 👤 山口　佐知子
• 👤 Yasuo Iwaki
• 👤 岩城　康雄
• 👤 Yuzo Hayashi
• 👤 林　勇藏
• 👤 Noboru Mitsuhida
• 👤 光飛田　登
• 👤 Minoru Ando
• 👤 實 安藤

Bibliographic Details