Water-soluble porphyrin derivative

Abstract

Abstract NEW MATERIAL:A water-soluble porphyrin derivative of formulaI(R1 is H2, formula II; R2 is ethyl, formula III; when R1 is formula II, R2 is formula III; EN is residue of ethylenediamine). EXAMPLE:Methylpyropheophorbide ethylenediamine hydrochloride. USE:It is used for detection of cancer tissues, eradication of cancer cells and as a synthetic intermediate of various kinds of compounds. Further, it shows no antimicrobial effect against yeasts and fungi but selectively shows against bacteria. Moreover, it shows strong antibacterial effect against gram-positive bacteria and so it is used as an aitibacterial. PREPARATION:The reaction between of a chlorophyl derivative of formula IV (R3 is H2, COOCH3; R4 is CH=CH2, ethyl, when R3 is COOCH3, R4 is CH=CH2) and ethylenediamine is followed by addition of hydrochloric acid to give the compound of formulaI.

Inventors

• 👤 Haruki Rai
• 👤 頼　春樹
• 👤 Hidetoshi Taketomi
• 👤 武富　英俊
• 👤 Kunio Suzuki
• 👤 鈴木　邦男
• 👤 Toyokazu Tachikawa
• 👤 立川　東洋一

Bibliographic Details