Nifedipine preparation with prolonged action

Abstract

Abstract PURPOSE:A nifedipine preparation with prolonged action that is made by combining a nifedipine rapid=releasing composition with a slow-releasing composition at a specific weight ratio, thus improving the absorbability of nifedipine and the action-prolonging properties and being used for prevention and treatment of angina pectoris and hypertension. CONSTITUTION:A rapidly releasing composition containing a fine powder of nifedipine of less than 5mu, preferably 1-4mu average particle size as an active ingredient, and a solwly releasing composition that contains a fine powder of nifedipine of less than 5mu average particle size, of which the surface is coated with a nontoxic film consisting of a substance hard soluble in water such as oil, e.g., hardened oil or ethylcellulose and of an enteric high polymer such as cellulose acetate phthalate, are combined so that the weight ratio of nifedipine ranges from 15/85-50/50 to give the objective nifedipine preparation with prolonged action. The above-stated average particle size gives increased absorbability of nifedipine and prolongs higher concentration of the active ingredient in blood and the coating ensures the slow and prolonged release of nifedipine.

Inventors

• 👤 Isao Sugimoto
• 👤 杉本　功
• 👤 Kazunori Togo
• 👤 東郷　和紀
• 👤 Kozo Sasaki
• 👤 佐々木　廣三
• 👤 Atsushi Yamagata
• 👤 山県　敦
• 👤 Akira Kuchiki
• 👤 朽木　彰

Bibliographic Details