Preparation of ee type monosubstituted cycloheaxane-1- carbonyl compound

Abstract

Abstract PURPOSE: To convert an ea type or ae type isomer of monsubstituted cyclohexane-1- carbonyl compound to ee type isomer with high isomerization ratio, by heating the ea type or ae type isomer of monsubstituted cyclohexane-1-carbonyl compound using a proton donative substance or electron attractive substance as a catalyst at specific temperature. CONSTITUTION: An ea type or ae type isomer of monosubstituted cyclohexane-1- carbonyl compound is heated in the presence of a catalyst at 50W400°C, to give its ee type isomer. A substance having proton donative properties or electron attractive properties, especially liquid or solid acid (e.g., H 2 SO 4 , H 3 PO 4 , H 3 BO 3 , and carboxylic acid) having a relatively high boiling point, is preferably used as the catalyst, and its amount used is small 1W3wt% based on raw material. The temperature is 80W120°C when the catalyst is sulfuric anhydride type or halosulfonic acid type compound, and 200W350°C when a catalyst other than the compound is used. EFFECT: Time required for isomerization is short (15min to three hours), and side reactions, will hardly occur. COPYRIGHT: (C)1981,JPO&Japio

Inventors

• 👤 Kaoru Koto
• 👤 Tsunenori Fujii
• 👤 Shigetaka Hoshino

Bibliographic Details