Novel furanes and lactones from streptomyces

Abstract

Abstract NEW MATERIAL: A compd. represented by the formula (wherein R 1 is H or oxo, R 2 is methyl or l-hydroxyethyl, R 3 is H, methyl or rhamnosyloxycarbonyl, R 4 is H, 2-hydroxypropyl, acetoxy or methyl and bonds between C 1 and C 2 and between C 3 and C 4 are a double bond). USE: An antibacterial agent. PROCESS: For example, DSM 4349, DSM 4355, DSM 200 and DSM 4211 of the genus Streptomyces and mutuants of them are mixed in a nutreient medium to be subjected to shaking culture at 27°C for 10-14 days and this culture medium is centrifugally separated to collect a supernatant soln. and ethyl acetate is added to this soln. to extract a product and the extract is purified by silica gel chromatography to obtain the compd. represented by the formula. COPYRIGHT: (C)1990,JPO

Inventors

• 👤 Susanne Grabley
• 👤 ズザネ・グラープライ
• 👤 Joachim Wink
• 👤 ヨーアヒム・ヴインク
• 👤 Klaus Kuehlein
• 👤 クラウス・キユーライン
• 👤 Gerhard Seibert
• 👤 ゲールハルト・ザイベルト
• 👤 Klaus Huetter
• 👤 クラウス・ヒユター
• 👤 Hermann Uhr
• 👤 ヘルマン・ウーア
• 👤 Axel Zeeck
• 👤 アクセル・ツエーク

Bibliographic Details