2,2-dimethylchromene derivative, its manufacture, and drug composition containing it

Abstract

Abstract NEW MATERIAL: Compd. of formula I (wherein Z is a halogen, CN, NO 2 , acetyl, a phosphono, a dialkoxyphosphoryl and a 1-3C alkoxy) and pharmacologically allowable salts of the above described phosphono group. EXAMPLE: 6-Cyano-4-(1,2-dihydro-2-oxopyrido-1-yl)-2,2-dimethyl-chromene. USE: Antihypertensive agent and antiarrhythmic agent. PROCESS: A compd. of formula II (wherein Z' is a halogen, CN, NO 2 , acetyl and a dialkoxyphosphoryl) is dehydrated and then, if necessary, dialkyoxyphosphoryl group is transformed to phosphono group to obtain a compd. of formula I. In addition, dose per day of the compd. of formula I for attaining a required preventive or curing effect is 0.1-5 mg/kg (body wt.) and as each dose unit, 5-200 mg compd. of formula I are incorporated by mixing the compd. with a shaping agent for medicine. COPYRIGHT: (C)1990,JPO

Inventors

• 👤 Georges Garcia
• 👤 ジョルジュ・ガルシア
• 👤 Alain D Malta
• 👤 アラン・デイ・マルタ
• 👤 Patrick Gautier
• 👤 パトリック・ゴウテイエ

Bibliographic Details