Antiphlogistic analgesic composition having high percutaneous absorption

Abstract

Abstract PURPOSE:To obtain an antiphlogistic analgesic composition having excellent percutaneous absorption and good feeling in use without stimulating a skin, containing an aiti-inflammatory drug, hydrogenated phospholipid, urea, aliphatic alcohol and water. CONSTITUTION:An anti-inflammatory drug is blended with a hydrogenated phospholipid (e. g., phosphatidylcholine), urea, >=8C aliphatic alcohol (e. g., octanol) and water as essential components, and, if necessary, a dispersion auxiliary such as polymer thickening agent or surfactant and additives such as humectant or antiseptic and pharmaceutically manufactured to give the aimed substance. The substance can be processed into a dosage form such as lotion agent, gel agent, cream agent, spray agent, cataplasma, etc. The amount of the hydrogenated phospholipid in the preparation is 1-20wt.%, those of urea and the aliphatic alcohol are 1-10wt.%, respectively.

Inventors

• 👤 Ko Kamata
• 👤 鎌田　皎
• 👤 Toshiaki Nishihata
• 👤 西畑　利明
• 👤 Koichi Matsumoto
• 👤 宏一 松本

Bibliographic Details