New derivatives of 4-chloro-5-sulfamoyl-antheranilic acid their preparation and pharmaceutical compositions comprising them

Abstract

Abstract New derivatives of 4-chloro-5-sulfamoyl-anthranilic acid. In the new derivatives the 5-sulfamoyl group is substituted by R1XCH2, where X is oxygen or sulfur and R1 is a straight or branched-chain lower alkyl radical of up to 10 carbon atoms which may be substituted by a hydroxy or alkoxy group or several such groups, a cycloalkyl radical, an alkenyl or alkinyl radical, an aralkyl or heteroarylalkyl radical. The novel compounds are valuable diuretics and saluretics and they are prepared from corresponding free sulfamoyl compounds by reaction with formaldehyde or paraformaldehyde and a compound R1-XH where R1 and X have the same meaning as above. [US3860582A]

Inventors

• 👤 S Schoenberg
• 👤 H Yellin

Bibliographic Details