GB2204792A
Expired / Lapsed
GB
⏱️ 0.0 years remaining
Cefuroxime axetil compositions
Assignee: Glaxo Group Ltd
•
Filing: 1988-05-13
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Granted: —
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Expires: 2008-05-13
Abstract
No abstract record available.
Inventors
- 👤 Michael Bernard James
- 👤 Leonard Godfrey Elliott
Bibliographic Details
Application Number
—
Jurisdiction
GB
Data Source
google_patents
Last Synchronized
2026-11-09 17:21
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0087; A61K9/0095; A61K31/00; A61K31/33; A61K31/395; A61K31/54; A61K31/542; A61K31/545; A61K9/14; A61K9/16; A61K9/1605; A61K9/1617; A61K9/1629; A61K9/1652; A61K9/48; A61K9/50; A61K9/5005; A61K9/5015; A61P; A61P31/00; A61P31/04
Claims Analysis
Total Claims: 33
Claim 1
Independent Claim
52 words
A composition comprising cefuroxime axetil in particulate form, the particles being provided with integral coatings of a lipid or a mixture of lipids, which are insoluble in water and which serve to mask the bitter taste of cefuroxime axetil upon oral administration but which disperse or dissolve on contact with gastro-intestinal fluid.
Claim 2
Dependent Claim
52 words
A composition comprising cefuroxime axetil in particulate form, the particles being provided with integral coatings of a lipid or a mixture of lipids, which are insoluble in water and which serve to mask the bitter taste of cefuroxime axetil upon oral administration but which disperse or dissolve on contact with gastro-intestinal fluid.
Claim 3
Dependent Claim
26 words
A composition as claimed in claim 1 wherein the lipid or mixture of lipids has a melting point in the range of from 30 to 800C.
Claim 4
Dependent Claim
26 words
A composition as claimed in claim 2 wherein the lipid or mixture of lipids has a melting point in the range of from 40 to 700C.
Claim 5
Dependent Claim
30 words
A composition as claimed in claim 1 wherein the lipid or mixture of lipids comprises one or more straight chain aliphatic carboxylic acids having from 10 to 30 carbon atoms.
Claim 6
Dependent Claim
31 words
A composition as claimed in claim 4 wherein the mixture of lipids comprises a mixture of stearic and palmitic acids in a ratio of from 3:7 to 7:3 25 by weight.
Claim 7
Dependent Claim
24 words
A composition as claimed in claim 5 wherein the mixture of stearic and palmitic acids is in a ratio of about 1:1 by weight..
Claim 8
Dependent Claim
19 words
A composition as claimed in any preceding claim containing from 5 to 90% by weight of cefuroxime axetil. 4
Claim 9
Dependent Claim
17 words
A composition as claimed in claim 7 containing from 10 to 30% by weight of cefuroxime axetil.
Claim 10
Dependent Claim
13 words
A composition as claimed in any preceding claim 5 containing amorphous cefuroxime axetil.
Claim 11
Dependent Claim
21 words
A composition as claimed in claim 9 wherein the cefuroxime axetil is spray-dried cefuroxime axetil in the form of hollow microspheres.
Claim 12
Dependent Claim
22 words
A composition as claimed in any preceding claim wherein the coated particles have diameters in the range from 1 to 250 microns
Claim 13
Dependent Claim
23 words
A composition as claimed in any preceding claim wherein the coated particles have a mean diameter by volume of less than 100 microns.
Claim 14
Dependent Claim
52 words
A process for the preparation of a composition as claimed in claim 1 which comprises dispersing particulate cefuroxime axetil in a molten lipid or mixture of lipids, atomising the dispersion to provide particles having integral coatings of the lipid or mixture of lipids and cooling and collecting the coated particles thereby obtained.
Claim 15
Dependent Claim
24 words
A process as claimed in claim 13 wherein the lipid or mixture of lipids is as defined in any of claims 2 to 6.
Claim 16
Dependent Claim
20 words
A process as claimed in claim 13 or claim 14 wherein the dispersion is atomised by a pneumatic nozzle atomiser.
Claim 17
Dependent Claim
21 words
A process as claimed in claim 15 wherein the atomiser is an internal mixing two-fluid nozzle atomiser. 23 - . 1
Claim 18
Dependent Claim
40 words
A process as claimed in claim 15 or claim 16 wherein the molten dispersion is atomised at a temperature which is in the range of 10 to 200C above the melting point of the lipid or mixture of lipids used.
Claim 19
Dependent Claim
35 words
A process as claimed in any of claims 15 to 17 wherein the particulate cefuroxime axetil prior to coating has a mean particle diameter by volume in the range of from 5 to 50 microns.
Claim 20
Dependent Claim
41 words
A process as claimed in any of claims 15 to 18 wherein the amounts of particulate cefuroxime axetil and lipid or lipid mixture used are such as to provide coated particles containing from 5 to 50% by weight of cefuroxime axetil.
Claim 21
Dependent Claim
37 words
A process as claimed in claim 19 wherein the amounts of particulate cefuroxime axetil and lipid or lipid mixture used are such as to provide coated particles containing from 5 to 30% by weight of cefuroxime axetil.
Claim 22
Dependent Claim
30 words
A process as claimed in any of claims 15 to 20 wherein the dispersion is atomised to provide coated particles having diameters in the range from 1 to 250 microns.
Claim 23
Dependent Claim
31 words
A process as claimed in any of claims 15 to 21 wherein the dispersion is atomised to provide coated particles having a mean diameter by volume of less than 100 microns.
Claim 24
Dependent Claim
31 words
A process as claimed in claim 22 wherein the -,' dispersion is atomised to provide coated particles having a mean diameter by volume of from 20 to 100 microns. 1 1
Claim 25
Dependent Claim
28 words
A process as claimed in claim 23 wherein the dispersion is atomised to provide coated particles having a mean diameter by volume of from 30 to 60 microns.
Claim 26
Dependent Claim
35 words
A pharmaceutical composition for oral administration comprising a composition as claimed in claim 1, or as prepared by a process as claimed in claim 13, together with one or more pharmaceutical carriers 10 or excipients.
Claim 27
Dependent Claim
14 words
A pharmaceutical composition as claimed in claim 25 in the form of granules. 2
Claim 28
Dependent Claim
15 words
A pharmaceutical composition as claimed in claim 25 in the form of an aqueous suspension.
Claim 29
Dependent Claim
26 words
A pharmaceutical composition as claimed in claim 27 containing an orally acceptable solute serving 0 to assist in maintaining the taste-masking properties of the lipid coating.
Claim 30
Dependent Claim
23 words
A pharmaceutical composition as claimed in claim 28 wherein the solute is sugar in the concentration 25 range 50 to 85 weight percent.
Claim 31
Dependent Claim
12 words
A pharmaceutical product as claimed in claim 1, substantially as herein described.
Claim 32
Dependent Claim
11 words
A process as claimed in claim 13 substantially as herein described.
Claim 33
Dependent Claim
56 words
A pharmaceutical composition as claimed in claim 25 substantially as herein described. Published 1988 at The Patent Office, State House, 66/71 High Holborn, London WCIR 4TP. Further copies may be obtained from The Patent Office, Sales Branch, St Mary Cray, Orpington, Kent BR5 3RD. Printed by Multiplex techniques ItAl, St Mary Gray, Kent. 00n. 1187. T
References Cited (Backward Citations)
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