GB2073219A
Expired / Lapsed
GB
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Polymer surfaces for blood- contacting surfaces of a biomedical device, and methods for forming
Assignee: Thoratec LLC
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Filing: 1981-02-23
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Granted: —
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Expires: 2001-02-23
Abstract
Abstract A polymer mixture is formed from at least 95 volume % of a base polymer and less than 5 volume % of a polymer additive including at least first and second different chains in graft or block copolymer form. The first chains are characterized by a low critical surface tension but have a tendency to exude from the mixture while the second ones lower this tendency. This polymer mixture is formed into the exposed blood- contacting surface of a biochemical devlce. A preferred additive is a block copolymer of (a) polydialkyl siloxanes and (b) a polyurethane, with the base polymer being a polyurethane.
Inventors
No inventors recorded.
Bibliographic Details
Application Number
—
Jurisdiction
GB
Data Source
google_patents
Last Synchronized
2026-10-23 12:45
CPC Classifications
C; C08; C08L; C08L83/00; C08L83/10; C08L83/12; A; A61; A61L; A61L33/00; A61L33/06; A61L33/062; A61L33/068; C08G; C08G18/00; C08G18/06; C08G18/08; C08G18/10; C08G18/28; C08G18/40; C08G18/61; C08G77/00; C08G77/42; C08G77/452; C08G77/455; C08G77/458; C08G77/46; C08L75/00; C08L75/04
Claims Analysis
Total Claims: 59
Claim 1
Independent Claim
134 words
In a method of forming the exposed bloodcontacting surface of a biomedical device, or components thereof, the steps of
(a) thoroughly dispersing no greater than about 5 volume % of a polymer additive throughout at least 95 volume % of a base polymer, while said polymer additive and base polymer are in fluid form, to form a polymer admixture, said polymer additive comprising a first homopolymer chain component chemically bonded to at least a second homopolymer chain component of a different type than said first component, said polymer additive being characterized by a Pc less than said base polymer and said polymer admixture being characterized by a Pc between about 10 and 35 dyne/cm.; and
(b) solidifying said polymer admixture and forming it into the blood-contacting surface of a biomedical device or component thereof.
Claim 2
Dependent Claim
134 words
In a method of forming the exposed bloodcontacting surface of a biomedical device, or components thereof, the steps of
(a) thoroughly dispersing no greater than about 5 volume % of a polymer additive throughout at least 95 volume % of a base polymer, while said polymer additive and base polymer are in fluid form, to form a polymer admixture, said polymer additive comprising a first homopolymer chain component chemically bonded to at least a second homopolymer chain component of a different type than said first component, said polymer additive being characterized by a Pc less than said base polymer and said polymer admixture being characterized by a Pc between about 10 and 35 dyne/cm.; and
(b) solidifying said polymer admixture and forming it into the blood-contacting surface of a biomedical device or component thereof.
Claim 3
Dependent Claim
33 words
The method of Claim 1 in which said first component is characterized by a yc less than 30 dyne/cnn. and a tendency to exudate, and said second component lowers said tendency to exudate.
Claim 4
Dependent Claim
28 words
The method of Claim 1 in which said first component is a homopolymar selected from the group consisting of polydialkylsiloxanes, polyfluoroalkyl alkylsiloxanes, polyalkylene oxides, polyolefins, polydienes and polyfluorocarbons.
Claim 5
Dependent Claim
12 words
The method of Claim 3 in which said first component is poly(dimethylsiloxane).
Claim 6
Dependent Claim
20 words
The method of Claim 1 in which said first component is a polydialkylsiloxane, and said second component is a polyurethane.
Claim 7
Dependent Claim
22 words
The method of Claim 1 in which said second component and said base polymer are formed of the same type of homopolymer.
Claim 8
Dependent Claim
53 words
The method of Claim 11 in which said base polymer includes end groups capable of hydrogen bonding or reacting with protein, together with the step of fractionating said base polymer to remove a lower molecular weight fraction to reduce the hydrogen bonding capacity of the remaining base polymer prior to said dispersion step.
Claim 9
Dependent Claim
14 words
The method of Claim 1 together with the step of annealing said polymer admixture.
Claim 10
Dependent Claim
27 words
The method of Claim 1 in which about 0.00002 to 2 volume % polymer additive is added to said base polymer based on the total polymer admixture.
Claim 11
Dependent Claim
21 words
The method of Claim 1 in which said polymer additive comprises at least about 20 volume % of said first component.
Claim 12
Dependent Claim
32 words
The method of Claim 1 in which said polymer additive comprises about 20 to 80 volume % of said first component and about 20 to 80 volume % of said second component.
Claim 13
Dependent Claim
22 words
The method of Claim 1 in which said polymer admixture is deposited as a film onto a biomedical device or component thereof.
Claim 14
Dependent Claim
22 words
The method of Claim 1 in which said additive and base polymer are in molten form during dispersion and solidify on cooling.
Claim 15
Dependent Claim
26 words
The method of Claim 1 in which said polymer admixture is dissolved in solvent during mixing and said solvent is removed to solidify said polymer admixture.
Claim 16
Dependent Claim
23 words
1 5. The method of Claim 1 in which said base polymer comprises a curable thermosetting fluid polymer which is solidified by curing.
Claim 17
Dependent Claim
25 words
The method of Claim 1 in which said polymer additive comprises a linear multiblock copolymer with blocks of at least said first and second components.
Claim 18
Dependent Claim
30 words
The method of Claim 1 in which said polymer additive comprises a graft copolymer with a substrate formed of said first component and pendant chains formed of said second component.
Claim 19
Dependent Claim
30 words
The method of Claim 1 in which said polymer additive comprises a graft copolymer with a substrate formed of said second component and pendant chains formed of said first component.
Claim 20
Independent Claim
115 words
A method of forming a polymer of low surface free energy comprising the steps of
(a) reacting about 0.0002 to 2 volume % of a homopolymer additive with at least 98 volume % of a base polymer, while said homopolymer additive and base polymer are in fluid form to form a fluid polymer admixture of at least 95 volume % pure base polymer and no greater than 5 volume % of a copolymer of said base polymer and said homopolymer additive, and
(b) solidifying said polymer admixture, said additive polymer being characterized by a Pc less than said base polymer and said polymer admixture being characterized by a Yc between about 10 and 35 dyne/cm.
Claim 21
Independent Claim
115 words
A method of forming a polymer of low surface free energy comprising the steps of
(a) reacting about 0.0002 to 2 volume % of a homopolymer additive with at least 98 volume % of a base polymer, while said homopolymer additive and base polymer are in fluid form to form a fluid polymer admixture of at least 95 volume % pure base polymer and no greater than 5 volume % of a copolymer of said base polymer and said homopolymer additive, and
(b) solidifying said polymer admixture, said additive polymer being characterized by a Pc less than said base polymer and said polymer admixture being characterized by a Yc between about 10 and 35 dyne/cm.
Claim 22
Dependent Claim
23 words
The method of Claim 19 in which said polymer admixture is formed into the bloodcontacting surface of a biomedical device or component thereof.
Claim 23
Dependent Claim
97 words
A biomedical device or component of the same, including a blood-compatible, bloodcontacting surface formed of a polymer admixture comprising at least 95 volume % of a base polymer and no greater than 5 volume % of a polymer additive comprising a first homopolymer chain component chemically bonded to at least a second homopolymer chain component of a different type than said first component, said polymer additive being dispersed throughout said base polymer and being characterized by a yc less than said base polymer, said polymer admixture being characterized by a Pc between about 10 and 35 dyne/cm.
Claim 24
Dependent Claim
97 words
A biomedical device or component of the same, including a blood-compatible, bloodcontacting surface formed of a polymer admixture comprising at least 95 volume % of a base polymer and no greater than 5 volume % of a polymer additive comprising a first homopolymer chain component chemically bonded to at least a second homopolymer chain component of a different type than said first component, said polymer additive being dispersed throughout said base polymer and being characterized by a yc less than said base polymer, said polymer admixture being characterized by a Pc between about 10 and 35 dyne/cm.
Claim 25
Dependent Claim
34 words
The biomedical device of Claim 21 in which said first component is characterized by a Pc less than 30 dyne/cm. and a tendency to exudate, and said second component lowers said tendency to exudate.
Claim 26
Dependent Claim
29 words
The biomedical device of Claim 21 in which said first component is a homopolymer selected from the group consisting of polydialkylsiloxanes, polyfluoroalkyl alkylsiloxanes, polyalkylene oxides, polyolefins, polydienes and polyfluorocarbons.
Claim 27
Dependent Claim
13 words
The biomedical device of Claim 21 in which said first component is poly(dimethylsiloxane).
Claim 28
Dependent Claim
21 words
The biomedical device of Claim 21 in which said first component is a polydialkylsiloxane and said second component is a polyurethane.
Claim 29
Dependent Claim
21 words
The biomedical device of Claim 21 characterized by blood compatibility in the form of a blood contact device or component thereof.
Claim 30
Dependent Claim
27 words
The biomedical device of Claim 21 characterized by blood compatibility in the form of a blood contact layer adhered to the surface of a blood contact device.
Claim 31
Dependent Claim
30 words
The biomedical device of Claim 21 in which a portion of said polymer additive is in the form of a continuous layer on the surface of a blood contact device.
Claim 32
Dependent Claim
37 words
The biomedical device of Claim 21 in which a portion of said polymer additive comprises a linear multi-block copolymer with blocks of at least said first and second component on the surface df a blood contact device.
Claim 33
Dependent Claim
42 words
The biomedical device of Claim 21 in which a portion of said polymer additive comprises a graft copolymer with a substrate formed of said first component and pendant chains formed of said second component on the surface of a blood contact device.
Claim 34
Dependent Claim
42 words
The biomedical device of Claim 21 in which a portion of said polymer additive comprises a graft copolymer with a substrate formed of said second component and pendant chains formed of said second component on the surface of a blood contact device.
Claim 35
Dependent Claim
160 words
In a method of forming a polymer admixture of low surface free energy from a base polymer and polymer additive wherein said base polymer includes end groups capable of hydrogen bonding or reacting with protein, the steps of
(a) fractionating a base polymer to remove a lower molecular weight fraction to reduce the YG of the remaining base polymer,
(b) thoroughly dispersing no greater than about 5 volume % of a polymer additive throughout at least 95 volume % of a base polymer, while said polymer additive and base polymer are in fluid form, to form a polymer admixture, said polymer additive comprising a first homopolymer chain component chemically bonded to at least a second homopolymer chain component of a different type than said first component, said polymer additive being characterized by a yc less than said base polymer and said polymer admixture being characterized by a Pc between about 10 and 35 dyne/cm.; and
(c) solidifying said polymer admixture.
Claim 36
Dependent Claim
160 words
In a method of forming a polymer admixture of low surface free energy from a base polymer and polymer additive wherein said base polymer includes end groups capable of hydrogen bonding or reacting with protein, the steps of
(a) fractionating a base polymer to remove a lower molecular weight fraction to reduce the YG of the remaining base polymer,
(b) thoroughly dispersing no greater than about 5 volume % of a polymer additive throughout at least 95 volume % of a base polymer, while said polymer additive and base polymer are in fluid form, to form a polymer admixture, said polymer additive comprising a first homopolymer chain component chemically bonded to at least a second homopolymer chain component of a different type than said first component, said polymer additive being characterized by a yc less than said base polymer and said polymer admixture being characterized by a Pc between about 10 and 35 dyne/cm.; and
(c) solidifying said polymer admixture.
Claim 37
Dependent Claim
69 words
A blood-compatible polymer admixture comprising at least 95 volume % of a base polymer and no greater than 5 volume % of a polymer additive comprising a poly(dialkylsiloxane) segment chemically bonded to a polyurethane segment, said polymer additive being dispersed through said base polymer and being characterized by a yc less than said base polymer, said polymer admixture being characterized by a Pc between about 10 and 35 dyne/cm.
Claim 38
Dependent Claim
69 words
A blood-compatible polymer admixture comprising at least 95 volume % of a base polymer and no greater than 5 volume % of a polymer additive comprising a poly(dialkylsiloxane) segment chemically bonded to a polyurethane segment, said polymer additive being dispersed through said base polymer and being characterized by a yc less than said base polymer, said polymer admixture being characterized by a Pc between about 10 and 35 dyne/cm.
Claim 39
Dependent Claim
20 words
The polymer admixture of Claim 33 in the form of the blood contacting surface of a biomedical device or component.
Claim 40
Dependent Claim
15 words
The polymer admixture of Claim 33 in which said polymer additive is a graft copolymer.
Claim 41
Dependent Claim
15 words
The polymer admixture of Claim 33 in which said polymer additive is a block copolymer.
Claim 42
Dependent Claim
14 words
The polymer admixture of Claim 33 in which said base polymer is a polyurethane.
Claim 43
Dependent Claim
100 words
In a method of forming a blood-compatible polymer admixture, the steps of
(a) thoroughly dispersing no greater than about 5 volume % of a polymer additive throughout at least 95 volume % of a base polymer, while said polymer additive and base polymer are in fluid form, to form a polymer admixture, said polymer additive comprising a poly(dialkylsiloxane) segment component chemically bonded to a polyurethane segment, said polymer additive being characterized by a Pc less than said base polymer and said polymer admixture being characterized by a Pc between about 10 and 35 dyne/cm.; and
(b) solidifying said polymer admixture.
Claim 44
Dependent Claim
100 words
In a method of forming a blood-compatible polymer admixture, the steps of
(a) thoroughly dispersing no greater than about 5 volume % of a polymer additive throughout at least 95 volume % of a base polymer, while said polymer additive and base polymer are in fluid form, to form a polymer admixture, said polymer additive comprising a poly(dialkylsiloxane) segment component chemically bonded to a polyurethane segment, said polymer additive being characterized by a Pc less than said base polymer and said polymer admixture being characterized by a Pc between about 10 and 35 dyne/cm.; and
(b) solidifying said polymer admixture.
Claim 45
Dependent Claim
68 words
A blood-compatible polymer solid at 370C comprising a block polymer including a sequence of block segments represented by the formula
[A] [B] [C], in which A is a poly(alkylsiloxane), B is a hard block polymer segment with a crystalline
melting point above 370C or a glass transition temperature above 370C, and C is a hydrophilic polymer selected from the group consisting of polyethylene oxide and polyethylene oxidecopolypropylene oxide.
Claim 46
Dependent Claim
68 words
A blood-compatible polymer solid at 370C comprising a block polymer including a sequence of block segments represented by the formula
[A] [B] [C], in which A is a poly(alkylsiloxane), B is a hard block polymer segment with a crystalline
melting point above 370C or a glass transition temperature above 370C, and C is a hydrophilic polymer selected from the group consisting of polyethylene oxide and polyethylene oxidecopolypropylene oxide.
Claim 47
Dependent Claim
31 words
The polymer of Claim 39 blended with a
blood-incompatible base polymer in the ratio of at least 95 volume % base polymer and no greater than 5 volume % polymer additive.
Claim 48
Independent Claim
19 words
A method of forming the exposed bloodcontacting surface of a biomedical device, or components thereof substantially as hereinbefore described.
Claim 49
Independent Claim
19 words
A method of forming the exposed bloodcontacting surface of a biomedical device, or components thereof substantially as hereinbefore described.
Claim 50
Independent Claim
15 words
A method of forming a polymer of low surface free energy substantially as hereinbefore described.
Claim 51
Independent Claim
15 words
A method of forming a polymer of low surface free energy substantially as hereinbefore described.
Claim 52
Dependent Claim
13 words
A biomedical device or component of a biomedical device substantially as hereinbefore described.
Claim 53
Dependent Claim
13 words
A biomedical device or component of a biomedical device substantially as hereinbefore described.
Claim 54
Independent Claim
16 words
A method of forming a polymer admixture of low surface free energy substantially as hereinbefore described.
Claim 55
Independent Claim
16 words
A method of forming a polymer admixture of low surface free energy substantially as hereinbefore described.
Claim 56
Dependent Claim
8 words
A blood-compatible polymer admixture substantially as hereinbefore described.
Claim 57
Dependent Claim
8 words
A blood-compatible polymer admixture substantially as hereinbefore described.
Claim 58
Dependent Claim
7 words
A blood-compatible polymer substantially as hereinbefore described.
Claim 59
Dependent Claim
7 words
A blood-compatible polymer substantially as hereinbefore described.
References Cited (Backward Citations)
No citation records indexed.
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