AMIDES OF PARA-METHOXYCINNAMIC ACID AND UROCANIC ACID FOR USE AS SOLAR FILTERS; PROCESSES FOR OBTAINING, DERMO-PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM AND APPLICATIONS

Abstract

Abstract Translated from French DES DERIVES A FONCTION AMIDE OBTENUS PAR REACTION ENTRE DES DERIVES D'AMINES LINEAIRES, RAMIFIEES OU CYCLIQUES DE STRUCTURE AMINO-ACIDE OU PEPTIDIQUE ET L'ACIDE PARA-METHOXYCINNAMIQUE OU L'ACIDE UROCANIQUE ONT ETE PREPARES. CES COMPOSES SONT PRECONISES COMME FILTRES SOLAIRES SPECIFIQUES, ABSORBANT AUX ENVIRONS DE 310NM ET EVITANT LES PHENOMEMES ERYTHEMATEUX LORS DES EXPOSITIONS AU SOLEIL. LA STRUCTURE AMIDIQUE EST EN FAVEUR D'UNE AUGMENTATION DE LA STABILITE CHIMIQUE DE CES FILTRES PAR RAPPORT AUX ESTERS ACTUELLEMENT UTILISES ET LA CONDENSATION DES CHROMOPHORES A DES AMINO-ACIDES SOUFRES A ETE REALISEE DANS LE BUT D'AMELIORER LEUR ADHERENCE A LA PEAU. CES PRODUITS SONT PRECONISES COMME PRINCIPES ACTIFS DE PREPARATIONS DERMO-PHARMACEUTIQUES ET COSMETOLOGIQUES. DERIVATIVES WITH AMID FUNCTION OBTAINED BY REACTION BETWEEN DERIVATIVES OF LINEAR, BRANCHED OR CYCLIC AMINES OF AMINO-ACID OR PEPTIDIC STRUCTURE AND PARA-METHOXYCINNAMIC ACID OR UROCANIC ACID HAVE BEEN PREPARED. THESE COMPOUNDS ARE RECOMMENDED AS SPECIFIC SUN FILTERS, ABSORBING AT APPROXIMATELY 310NM AND AVOIDING ERYTHEMATIC PHENOMEMAS DURING SUN EXPOSURE. THE AMIDIC STRUCTURE IS IN FAVOR OF AN INCREASE IN THE CHEMICAL STABILITY OF THESE FILTERS COMPARED TO THE ESTERS CURRENTLY USED AND THE CONDENSATION OF CHROMOPHORES WITH SULFUR AMINO ACIDS HAS BEEN ACHIEVED WITH THE PURPOSE OF IMPROVING THEIR ADHESION TO THE SKIN. THESE PRODUCTS ARE RECOMMENDED AS ACTIVE INGREDIENTS OF DERMOPHARMACEUTICAL AND COSMETOLOGICAL PREPARATIONS.

Inventors

• 👤 Dominique Robert
• 👤 Louis Jung

Bibliographic Details