EP1102194A2
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System for the extrapolation of glucose concentration
Assignee: Roche Diagnostics GmbH
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Filing: 2000-11-14
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Granted: —
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Expires: 2020-11-14
Abstract
Abstract System for the extrapolation of a glucose concentration comprising a data input device (EI) for entering administered insulin doses (I i ) and their times of administration (t i ), a data input device (EK) for entering the carbohydrates (KHj) consumed or to be consumed, a unit (GM) for determining an actual glucose concentration (G a ) at a point in time (t a ) in a patient's bodily fluid, a memory unit (M) for storing the insulin doses that have been administered, their times of administration, carbohydrate units consumed and their times of consumption, an evaluation unit (CPU) for evaluation of the data stored in the memory unit, and for the extrapolation of a glucose concentration at a point in time t p , whereby t p is after t a , and in which the extrapolation comprises the following steps: Determination of the portion (I wirk ) of insulin doses that become effective between t a and t p ; Determination of the portion of consumed carbohydrate units KH wirk , that become effective between t a and t p ; Determination of an extrapolated glucose concentration G p at the point in time t p with consideration for I wirk and KH wirk . The invention also provides a method for the extrapolation a glucose concentration and a system for the determination of insulin doses to be administered.
Inventors
- 👤 Brit Dr. Kalatz
- 👤 Udo Dr. Hoss
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-09 13:54
CPC Classifications
G; G16; G16H; G16H40/00; G16H40/60; G16H40/63; G16H15/00; G16H20/00; G16H20/10; G16H20/17; A; A61; A61B; A61B5/00; A61B5/145; A61B5/14532
Claims Analysis
Total Claims: 31
Claim 1
Independent Claim
215 words
System for the extrapolation of a glucose concentration, comprising a data input device (EI) for entering insulin doses administered (I i ) and their
times of administration (t i ), the same or a second data input device (EK) for entering carbohydrates (KH j )
consumed or to be consumed, and their times of consumption (t j ), a unit (GM) for determining the actual glucose concentration (G a ) in a
patient's bodily fluid at a specific point in time (t a ), a memory unit (M) for storing administered insulin doses and their times of
administration, and carbohydrates consumed and their times of consumption, an evaluation device (CPU) for evaluating the data stored in the memory unit
and extrapolating a glucose concentration at a point in time (t p ), whereby t p is
after t a , and the extrapolation comprises the following steps: determination of the portion (I wirk ) of insulin doses that take effect within the
interval between t a and t p , determination of the portion KH wirk of carbohydrates consumed that take
effect in the interval between t a and t p , determination of an extrapolated glucose concentration G p at the point in time
tp with consideration for I wirk and KH wirk .
Claim 2
Dependent Claim
69 words
System according to Claim 1, in which the glucose concentration G p is
determined at the point in time t p using the following formula: G p = G a - I wirk *D * SE + KH wirk * E + X, whereby D is an empirical weighting factor, SE is the patient's insulin sensitivity,
E is a factor, and X = 0 or is unequal to zero.
Claim 3
Dependent Claim
27 words
System according to Claim 2, in which E = R KH * F, whereby R KH is the
carbohydrate reduction factor and F is an empirical factor.
Claim 4
Dependent Claim
55 words
System according to Claim 2, in which X, as the addend contains the quantity G B = I basal * SE * C or is equal to G B , whereby I basal is the patient's basal insulin
demand over 24 hours, SE is the patient's insulin sensitivity, and C is an empirical
weighting factor.
Claim 5
Dependent Claim
43 words
System according to Claim 2 or 4, in which X, as the addend, contains the
quantity SG * A, whereby SG is the slope of the glucose concentration at the
point in time t a , and A is an empirical weighting factor.
Claim 6
Dependent Claim
22 words
System according to Claim 1, in which the unit used to determine the actual
glucose concentration G a is a microdialysis device.
Claim 7
Dependent Claim
20 words
System according to Claim 1 that also includes a display unit for displaying the
extrapolated glucose concentration G p .
Claim 8
Dependent Claim
29 words
System according to Claim 1 that also includes a warning unit that emits a
warning signal when the extrapolated glucose concentration G p is outside a
selected normal range.
Claim 9
Dependent Claim
17 words
System according to Claim 1 in which the user enters the carbohydrate units
consumed (KH j ).
Claim 10
Dependent Claim
58 words
System according to Claim 1 in which the system contains a control unit for an
insulin infusion device or is connected to such a device, and in which the insulin
doses administered (I i ) and their times of administration (t i ) are transmitted from
the control unit to the data input device for entering insulin doses.
Claim 11
Dependent Claim
66 words
System according to Claim 1 or 2 in which the portion of insulin doses (I wirk ) that
take effect in the period between t a and t p is calculated using the following
formula number of insulin doses to be considered whereby CI represents the quantity of insulin that is bioavailable at the point in
time t and therefore represents the insulin effectiveness profile; with
Claim 12
Dependent Claim
60 words
System according to Claim 1 or 2 in which the quantity of carbohydrates
consumed (KH wirk ) that takes effect in the period between t a and t p is calculated
using the following formula whereby C KH represents the quantity of carbohydrates that are bioavailable at the
point in time t and therefore represents the carbohydrate flooding profile, with
Claim 13
Dependent Claim
147 words
System for determination of insulin doses to be administered comprising a data input device (EI) for entering the insulin doses administered to the
patient (I i ) and their times of administration (t i ), a device (GM) for determining the actual glucose concentration G a in a
patient's bodily fluid at a specific point in time (t a ), a memory unit (M) for storing the doses of insulin administered and their
times of administration, an evaluation device (CPU) for evaluating the data stored in the memory unit,
and determination of an insulin dose to be administered subcutaneously, or a
carbohydrate intake whereby the evaluation comprises the following steps: determination of the portion (I wirk ) of insulin doses that are consumed within
the period between t a and t p , determination of the insulin doses to be administered, with consideration for
I wirk .
Claim 14
Dependent Claim
25 words
System according to Claim 1 or 13, in which the point in time t p is from 0.5 to 5
hours after t a .
Claim 15
Dependent Claim
32 words
System according to Claim 1 or 13, in which the point in time t p is at least 2 hours
after t a and up to 4 hours after t a .
Claim 16
Dependent Claim
34 words
System according to Claim 13, in which a glucose concentration G p is measured
at point in time t p and this glucose concentration is used to calculate the insulin
dose to be administered.
Claim 17
Dependent Claim
61 words
System according to Claim 16, in which the glucose concentration G p at the point
in time t p is calculated using the following formula: G p = G a - I wirk * D * SE + X, whereby D is an empirical weighting factor, SE is the patient's insulin sensitivity,
and X = 0 or is unequal to zero.
Claim 18
Dependent Claim
69 words
System according to one of Claims 13 - 17 that includes a data input device (EK)
for entering carbohydrate units consumed by a patient and their times of
consumption, and then determines the portion (KH wirk ) of carbohydrate units
consumed that take effect in the interval between t a and t p and takes KH wirk into
account in the determination of the insulin dose to be administered.
Claim 19
Dependent Claim
66 words
System according to Claim 18, in which the glucose concentration G p is
calculated at the point in time t p using the following formula: G p = G a + KH wirk * E - I wirk * SE D + X, whereby E and D are empirical weighting factors, SE is the patient's insulin
sensitivity, and X = 0 or is unequal to zero.
Claim 20
Dependent Claim
51 words
System according to Claim 17 or 19, in which X, as the addend, contains the
quantity G basal = I basal * SE * C, whereby I basal is the patient's basal insulin demand
over a 24-hour period, SE is the patient's insulin sensitivity, and C is an empirical
weighting factor.
Claim 21
Dependent Claim
42 words
System according to Claim 17 or 20 in which X, as the addend, contains the
quantity SG * A, whereby SG is the slope of glucose concentration at the point in
time t a , and A is an empirical weighting factor.
Claim 22
Dependent Claim
66 words
System according to Claim 16 or 17, in which the insulin dosage ID to be
administered subcutaneously is calculated using the following formula: ID = ((G p - G R ) / SE * E) + Y, whereby G R is a target glucose concentration or a maximum acceptable glucose
concentration, E is an empirical weighting factor, and Y = 0 or is unequal to zero.
Claim 23
Dependent Claim
70 words
System according to Claim 22, whereby Y = R KH * KH REST / SE * F is or contains
this value as the addend, whereby R KH is the patient's carbohydrate reduction
factor, KH REST is the quantity of carbohydrates resorbed between the actual point
in time (t a ) and the end of the period in which the insulin is effective, and F is an
empirical weighting factor.
Claim 24
Dependent Claim
24 words
System according to Claim 13, in which the quantity of insulin to be administered
is calculated in intervals of from 1 to 30 minutes.
Claim 25
Dependent Claim
18 words
System according to Claim 13 that contains a display unit for displaying the
insulin dose to be administered.
Claim 26
Dependent Claim
15 words
System according to Claim 13 that also contains a microdialysis device with a
microdialysis catheter.
Claim 27
Dependent Claim
16 words
System according to Claim 13 that has an administration unit for administering a
calculated insulin dose.
Claim 28
Dependent Claim
16 words
System according to Claim 27, in which the administration unit is integrated in
the microdialysis catheter.
Claim 29
Dependent Claim
34 words
System according to Claim 13 that contains a query unit that performs a query to
determine if a certain insulin dose should be administered and with which the user
releases the administration of insulin.
Claim 30
Dependent Claim
38 words
System according to Claim 13 that contains a warning unit that emits a warning
signal when an extrapolated glucose concentration G p leaves a normal range or
when an insulin dose to be administered exceeds a predefined quantity.
Claim 31
Dependent Claim
43 words
System according to Claim 13 or 27 that contains a display unit for displaying an
insulin dose to be administered, as well as an editing unit which the patient can
use to change the insulin dose to be administered before it is administered.
References Cited (Backward Citations)
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