EP0832618A1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Stent for dilating a stenotic lesion of a blood vessel
Assignee: Terumo Corp
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Filing: 1997-09-25
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Granted: —
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Expires: 2017-09-25
Abstract
Abstract A stent having long-term antithrombogenicity and radiopacity whose location and geometry can be radiographically confirmed is provided. The production method is also provided. The stent of the invention has an antithrombogenic agent covalently bonded on its surface, and the antithrombogenic agent is immobilized onto the stent surface through a coupling agent having at least two amino groups and a cross-linking agent having at least two aldehyde and/or epoxy groups. The stent of the invention may also have radiopaque metal plating on at least a part thereof.
Inventors
- 👤 Takashi Kitaoka
- 👤 Kazuhiko Hagiwara
- 👤 Yousuke Moriuchi
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 18:02
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/82; A61F2/86; A61F2/90; A61F2/91; A61F2/915; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0029; A61F2002/91516; A61F2002/91533; A61F2002/91541; A61F2002/9155; A61F2002/91558; A61F2002/91566; A61F2230/00; A61F2230/0002; A61F2230/0004; A61F2230/0013; A61F2250/00; A61F2250/0058; A61F2250/0067
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
56 words
A stent for dilating stenotic lesions of blood vessels
which comprises a substrate, wherein an antithrombogenic
agent is covalently bonded to the surface of said substrate
through a coupling agent having at least two amino groups
and a cross-linking agent having at least two aldehyde
and/or epoxy groups, said surface being treated with an
oxidizing agent.
Claim 2
Dependent Claim
12 words
A stent according to claim 1, wherein said oxidizing
agent is ozone.
Claim 3
Dependent Claim
15 words
A stent according to claim 1 or 2, wherein said
antithrombogenic agent is aminated heparin.
Claim 4
Dependent Claim
16 words
A stent according to one of claims 1 to 3, wherein
said substrate comprises stainless steel.
Claim 5
Dependent Claim
33 words
A stent according to one of claims 1 to 4, wherein
said coupling agent is at least one member selected from
the group consisting of polyethylene imine, polyethylene
glycol diamine, ethylenediamine, and tetramethylenediamine.
Claim 6
Dependent Claim
20 words
A stent according to one of claims 1 to 5, wherein
said cross-linking agent is glutaraldehyde or ethylene
glycol diglycidylether.
Claim 7
Dependent Claim
25 words
A stent according to one of claims 1 to 6, wherein
said surface is plated with a radiopaque metal on at least
a part thereof.
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