EP0796128B1
Expired / Lapsed
EP
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Transdermal system
Assignee: Novartis Pharma GmbH
•
Filing: 1995-11-27
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Granted: 1999-03-10
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Expires: 2015-11-27
Abstract
Abstract A transdermal system (1) for delivering a substance through the skin (2) has a reservoir (11) which stores the substance for delivery and a transfer device which in operation is connected to both the reservoir and the skin by means of passage openings. This transfer device comprises a sheet substrate (12) with up to about 30 % porosity. When the substance is delivered using an electrical field, the substrate sheet is a poor electrical conductor or essentially a nonconductor.
Inventors
- 👤 Carlo Stefan Effenhauser
- 👤 Andreas Manz
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-07 12:07
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/18; A61N1/20; A61N1/30; A61N1/303; A61M; A61M37/00; A61M37/0015; A61M2037/0007
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
70 words
A transdermal system (1) for transporting a substance through the skin (2), comprising
a reservoir (11) in which the substance to be transported is stored and a transfer device which,
in the operating state, is connected both to the reservoir (11) and to the skin by means of
openings, wherein the transfer device comprises a substrate sheet (12, 12a, 12b), the porosity
of which is up to approximately 30 %.
Claim 2
Dependent Claim
20 words
A transdermal system according to claim 1, wherein the substrate sheet (12, 12a, 12b)
is poorly conductive or substantially non-conductive.
Claim 3
Dependent Claim
84 words
A transdermal system according to one of claims 1 or 2, wherein on the surface of the
substrate sheet (12a, 12b) facing the skin (2), at least one rib with blades is provided, in which
rib a channel extends, the openings (120a, 120b) of which are connected at the proximal end
to the reservoir and at the distal end to the skin, the rib having an opening at the distal end,
whereby the distal opening extends substantially along the entire length of the rib.
Claim 4
Dependent Claim
19 words
A transdermal system according to claim 3, wherein the rib is substantially in the form
of a straight line.
Claim 5
Dependent Claim
19 words
A transdermal system according to claim 3, wherein the rib and its blades are in the
form of zigzags.
Claim 6
Dependent Claim
20 words
A transdermal system according to claim 3, wherein the rib and its blades are in the
form of curved lines.
Claim 7
Dependent Claim
31 words
A transdermal system according to claim 3, wherein numerous periodically recurring
structures are provided on the surface of the substrate sheet facing the skin, each individual
structure comprising ribs with blades.
Claim 8
Dependent Claim
23 words
A transdermal system according to any one of claims 3 to 7, wherein the blades of the
ribs are arranged offset in height.
Claim 9
Dependent Claim
56 words
A transdermal system according to claim 1, wherein numerous needles (123) are
provided on the surface of the substrate sheet facing the skin, in each of which needles there
extends a channel (121), the openings (120, 122) of which are connected at the proximal end
to the reservoir and at the distal end to the skin.
Claim 10
Dependent Claim
20 words
A transdermal system according to claim 9, wherein the needles (123) are of conically
narrowing construction at their distal end.
Claim 11
Dependent Claim
88 words
A transdermal system according to claim 9 or 10, wherein the length (L N ) of the
individual needles (123) is up to approximately 1000 µm, especially from approximately 1 µm
to 500 µm, and the total length (L K ) of the channel extending through each needle is from
approximately 1 µm to approximately 3000 µm, especially from approximately 10 µm to
1000 µm, and the diameter of the channel is from approximately 0.03 µm to approximately
300 µm, especially from approximately 0.1 µm to 100 µm.
Claim 12
Dependent Claim
58 words
A transdermal system according to any one of claims 1 to 11, comprising electrodes
(10) which are so arranged that they produce an electric current running from the reservoir
through the openings and the channels, which electric current transports the substance from
the reservoir through the openings (120, 122) and through the channels (121) into the skin (2).
Claim 13
Dependent Claim
37 words
A transdermal system according to any one of claims 3 to 12, wherein the density of
distribution of the needles (123) or of the ribs on the surface of the substrate sheet (12) facing
the skin varies.
Claim 14
Dependent Claim
37 words
A transdermal system according to any one of claims 1 to 13, wherein the substrate
sheet (12, 12a, 12b) is manufactured, preferably monolithically, by a micromechanical
manufacturing process, for example photolithography, X-ray lithography or electron beam
lithography.
References Cited (Backward Citations)
No citation records indexed.
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