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EP0794211A2 Expired / Lapsed EP ⏱️ 0.0 years remaining

Blends containing absorbable polyoxaamides

Assignee: Ethicon Inc
•
Filing: 1997-03-04
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Granted: —
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Expires: 2017-03-04
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Abstract

Abstract The present invention describes an aliphatic polyoxaamide polymer and blends thereof that may be used to produce surgical devices such as sutures, sutures with attached needles, molded devices, and the like. The aliphatic polyoxaamide of the present invention have a first divalent repeating unit of formula I: [X-C(O) -C(R 1 )(R 2 )-O-(R 3 )-O-C(R 1 )(R 2 )-C(O)-]     I and a second repeating unit selected from the group of formulas consisting of: [-Y-R 17 -] T ,     I [-O-R 5 -C(O)-] B , and     III ([-O-R 9 -C(O)] P -O-) L G     XI and combinations thereof, wherein X and Y are selected from the group consisting of -O- and -N(R)-, provided both X and Y are not both -O- and may be blended with a second polymer that is preferably biocompatable.

Inventors

  • 👤 Rao S. Bezwada
  • 👤 Dennis D. Jamiolkowski

Bibliographic Details

Application Number —
Jurisdiction EP
Data Source google_patents
Last Synchronized 2026-11-06 20:23
CPC Classifications
C; C08; C08G; C08G69/00; C08G69/44; A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2031; A61K9/204; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/225; A61L15/26; A61L15/42; A61L15/60; A61L17/00; A61L17/06; A61L17/10; A61L17/105; A61L27/00; A61L27/14; A61L27/18; A61L27/50; A61L27/52; A61L29/00; A61L29/04; A61L29/049; A61L29/06; A61L29/14; A61L29/145; A61L31/00; A61L31/04; A61L31/041; A61L31/06; C08G63/00; C08G63/66; C08G63/664; C08G63/668; C08G63/672; C08G69/40; C08L; C08L67/00; C08L67/02; C08L67/025; C08L77/00; C08L77/12; C09; C09D; C09D167/00; Y; Y10; Y10T; Y10T428/00; Y10T428/13; Y10T428/1352; Y10T428/1355; Y10T428/1362; Y10T428/24; Y10T428/249921; Y10T428/249953; Y10T428/29; Y10T428/2904; Y10T428/2913; Y10T428/2933; Y10T428/294; Y10T428/2942; Y10T428/2947; Y10T428/31504; Y10T428/31551

Claims Analysis

Total Claims: 10
Claim 1
Independent Claim 467 words
An aliphatic polyoxaamides comprising a first divalent repeating unit of formula I: [X-C(O)-C(R 1 )(R 2 )-O-(R 3 )-O-C(R 1 )(R 2 )-C(O)-]     I and a second repeating unit selected from the group of formulas consisting of: [-Y-R 17 -] T ,     II [-O-R 5 -C(O)-] B ,     III ([-O-R 9 -C(O)] P -O-) L G     XI and combinations thereof, wherein X and Y are selected from the group consisting of -O- and -N(R)-, provided that X and Y cannot both be -O-; R, R 1 and R 2 are independently selected from the group consisting of hydrogen and an alkyl group containing 1 to 8 carbon atoms; R 3 is selected from the group consisting of an alkylene unit and an oxyalkylene group of the following formula: -[(CH 2 ) C -O-] D -(CH 2 ) E -     IV wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer in the range of from 2 to 12; R 17 is an alkylene unit containing from 2 to 8 carbon atoms which may have substituted therein an internal ether oxygen, an internal -N(R 18 )- or an internal -C(O)-N(R 21 )-; T is an integer in the range of from 1 to 2,000; R 18 and R 21 are independently selected from the group consisting of hydrogen and an alkyl group containing 1 to 8 carbon atoms; R 5 and R 9 are selected from the group consisting of -C(R 6 ) (R 7 )-, -(CH 2 ) 3 -0-, -CH 2 -CH 2 -O-CH 2 -, -CR 8 H-CH 2 -, -(CH 2 ) 4 -,-(CH 2 ) F -0-C(O)- and -(CH 2 ) K -C(O)-CH 2 -; R 6 and R 7 are independently selected from the group consisting of hydrogen and an alkyl containing from 1 to 8 carbon atoms; R 8 is selected from the group consisting of hydrogen and methyl; F and K are independently selected integer in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200.
Claim 2
Dependent Claim 19 words
The aliphatic polyoxaamides of claim 1 wherein the number average molecular weight of formula III is less than 100,000.
Claim 3
Dependent Claim 64 words
The aliphatic polyoxaamides of claim 1 wherein the polymer has the formula: [(-C(O)-C(R 1 )(R 2 )-O-R 3 -O-C(R 1 )(R 2 )-C(O)-(Y-R 17 ) T -X) S (C(O)-R 5 -O) B ] W wherein S is an integer in the range of from about 1 to about 10,000 and W is an integer in the range of from about 1 to about 1,000.
Claim 4
Dependent Claim 66 words
The aliphatic polyoxaamides of claim 1 wherein the polymer has the formula: [(-C(O)-C(R 1 )(R 2 )-O-R 3 -O-C(R 1 )(R 2 )-C(O)-(Y-R 17 ) T -X) S ([-O-R 9 -C(O)] P -O-) L G) W wherein S is an integer in the range of from about 1 to about 10,000 and W is an integer in the range of from about 1 to about 1,000.
Claim 5
Dependent Claim 75 words
A polymer blend comprising an aliphatic polyoxaamide as defined in any one of claims 1 to 4 and a second polymer selected from the group consisting of homopolymers and copolymers of lactone type polymers with the repeating units described by formulas III and XI, aliphatic polyurethanes, polyether polyurethanes, polyester polyurethanes, polyethylene copolymers, polyamides, polyvinyl alcohols, poly(ethylene oxide), polypropylene oxide, polyethylene glycol, polypropylene glycol, polytetramethylene oxide, polyvinyl pyrrolidone, polyacrylamide, poly(hydroxy ethyl acrylate), poly(hydroxyethylmethacrylate) and combinations thereof.
Claim 6
Dependent Claim 26 words
A device made from an aliphatic polyoxaamide as defined in any one of claims 1 to 4 or a polymer blend as defined in claim 5.
Claim 7
Dependent Claim 74 words
The device of claim 6 wherein the device is an absorbable surgical device, such as an absorbable surgical device selected from the group consisting of burn dressings, hernia patches, medicated dressings, fascial substitutes, gauzes, fabrics, sheets, felts, sponges, gauze bandages, arterial grafts, bandages for skin surfaces, suture knot clips, pins, clamps, screws, plates, clips, staples, hooks, buttons, snaps, bone substitutes, intrauterine devices, tubes, surgical instruments, vascular implants, vascular supports, vertebral discs, and artificial skin.
Claim 8
Dependent Claim 20 words
The device of claim 6 wherein the device is an absorbable surgical filament which optionally is attached to a needle.
Claim 9
Dependent Claim 68 words
A device coated with an absorbable coating comprising an aliphatic polyoxaamide as defined in any one of claims 1 to 4, or a polymer blend as defined in claim 5, wherein the inherent viscosity of the polyoxaamide or the polymer blend is in the range of from about 0.05 to about 2.0 deciliters per gram (dl/g) as measured in a 0.1 g/dl solution of hexafluoroisopropanol (HFIP) at 25°C.
Claim 10
Dependent Claim 30 words
A drug delivery matrix comprising a drug and an aliphatic polyoxaamide as defined in any one of claims 1 to 4 or a polymer blend as defined in claim 5.

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