EP0705878A2
Expired / Lapsed
EP
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Compositions containing polyanionic polysaccharides and hydrophobic bioabsorbable polymers
Assignee: Genzyme Corp
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Filing: 1995-10-05
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Granted: —
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Expires: 2015-10-05
Abstract
Abstract Biocompatible compositions comprising polyanionic polysaccharides combined with hydrophobic bioabsorbable polymers as well as methods for making and using the compositions are described.
Inventors
- 👤 James W. Burns
- 👤 Keith E. Greenawalt
- 👤 Louis Masi
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-24 02:59
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/38; A61L27/3804; A61L27/14; A61L27/26; A61L31/00; A61L31/04; A61L31/041; A61P; A61P29/00; A61P31/00; A61P31/04
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
25 words
A water-insoluble biocompatible composition characterised in that it comprises a polyanionic polysaccharide combined with a hydrophobic bioabsorbable polymer and optionally a drug and/or biological cells.
Claim 2
Dependent Claim
20 words
A composition as claimed in claim 1 wherein the said polyanionic polysaccharide is in the form of a water-insoluble derivative.
Claim 3
Dependent Claim
35 words
A composition as claimed in claim 1 or claim 2 wherein the said polyanionic polysaccharide is selected from carboxymethylcellulose, carboxymethylamylose, hyaluronic acid, chondroitin-6-sulfate, heparin, heparin sulfate and dermatan sulfate, preferably carboxymethylamylose, carboxymethylcellulose or hyaluronic acid.
Claim 4
Dependent Claim
27 words
A composition as claimed in any of claims 1 to 3 wherein the said biocompatible composition comprises two or more polyanionic polysaccharides, preferably hyaluronic acid and carboxymethylcellulose.
Claim 5
Dependent Claim
45 words
A composition as claimed in any of claims 1 to 4 wherein the said hydrophobic bioabsorbable polymer is selected from polyglycolide, polylactide, polydioxanones, polyestercarbonates, polyhydroxyalkonates, polylactones and copolymers thereof, preferably polyglycolide, polylactide, a copolymer of polyglycolide/polylactide, a copolymer of polyglycolide/polycaprolactone or a copolymer of polylactide/polycaprolactone.
Claim 6
Dependent Claim
26 words
A composition as claimed in any of claims 1 to 5 wherein the said composition is in the form of a membrane, a foam or fibers.
Claim 7
Dependent Claim
59 words
A composition as claimed in any of claims 1 to 6 wherein the said drug is selected from proteins, biopolymers, steroids, non-steroidal anti-inflammatory drugs, cytotoxic agents, antibiotics and oligonucleotides, preferably a growth factor, such as TGF-β₂, which is capable of further enhancing the growth and proliferation of cells at a site of injury in a mammal, or an antibiotic.
Claim 8
Dependent Claim
23 words
A composition as claimed in any of claims 1 to 7 wherein the said composition is admixed or infiltrated with the said cells.
Claim 9
Dependent Claim
44 words
A composition as claimed in any of claims 1 to 8 wherein the said cells are derived from a mammal, preferably a human, and more preferably comprise fibroblasts, osteocytes, chondrocytes, keratinocytes, tenocytes, non-differentiated mesenchymal cells or a mixture of at least two cell types.
Claim 10
Independent Claim
34 words
A method of making a water-insoluble biocompatible composition as claimed in any of claims 1 to 9 characterised in that it comprises combining a polyanionic polysaccharide with a hydrophobic bioabsorbable polymer under suitable conditions.
Claim 11
Dependent Claim
21 words
A method as claimed in claim 10 wherein the said polyanionic polysaccharide is in the form of a film or foam.
Claim 12
Dependent Claim
107 words
A method as claimed in claim 10 or claim 11 wherein the said combination is achieved by coating preferably only one side of the said polyanionic polysaccharide with the said hydrophobic bioabsorbable polymer, by spraying the said hydrophobic bioabsorbable polymer onto the said polyanionic polysaccharide, by brushing the said hydrophobic bioabsorbable polymer onto the said water-insoluble polyanionic polysaccharide derivative, by dipping the said water-insoluble polyanionic polysaccharide derivative into the said hydrophobic bioabsorbable polymer, by dispersing fibers of the said hydrophobic bioabsorbable polymer into an aqueous suspension of the said polyanionic polysaccharide or by compressing a film of the said hydrophobic bioabsorbable polymer onto the said polyanionic polysaccharide.
Claim 13
Independent Claim
65 words
A method for promoting cell growth and proliferation characterised in that it in vitro comprises: obtaining a sample of the said cells; admixing the said cells with a water-insoluble biocompatible matrix which is a composition as claimed in any of claims 1 to 9; and culturing the said admixture under conditions suitable to promote growth and infiltration of the said cells into the said matrix.
Claim 14
Dependent Claim
57 words
A composition for promoting cell growth and proliferation in vivo at the site of an injury in a mammal characterised in that it comprises a sample of cells which are capable of facilitating healing of the said injury, admixed with a water-insoluble biocompatible matrix, which is a composition as claimed in any of claims 1 to 9.
Claim 15
Dependent Claim
40 words
A composition as claimed in claim 14 wherein the said admixture is cultured under conditions suitable to promote proliferation and infiltration of the said cells into the said matrix prior to placement at a site of injury in a mammal.
References Cited (Backward Citations)
No citation records indexed.
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