EP0699751A1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Antisense complementary to HCV genome
Assignee: Mitsubishi Chemical Corp
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Filing: 1993-08-25
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Granted: —
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Expires: 2013-08-25
Abstract
Abstract Antisense compounds which are complementary to a genome derived from hepatitis C virus (HCV) were provided. Because the antisense compounds of the present invention act specifically on mRNA of HCV and inhibits translation of HCV gene, they may be useful as an antiviral agent.
Inventors
- 👤 Makoto Seki
- 👤 Yoshikazu Honda
- 👤 Ei Yamada
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-31 02:47
CPC Classifications
C; C12; C12N; C12N15/00; C12N15/09; C12N15/11; C12N15/113; C12N15/1131; A; A61; A61P; A61P31/00; A61P31/12; C07; C07K; C07K14/00; C07K14/005; C12N15/63; C12N15/79; C12N15/85; C12N15/86; A61K; A61K38/00; C07K2319/00; C12N2310/00; C12N2310/10; C12N2310/11; C12N2310/111; C12N2310/30; C12N2310/31; C12N2310/312; C12N2310/315; C12N2310/33; C12N2310/337; C12N2770/00; C12N2770/00011; C12N2770/24011; C12N2770/24211; C12N2770/24222
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
70 words
An antisense compound having a sequence complementary to a base sequence which consists of 10-34 bases and is extracted from: (i) 93 bases from thymine at position 107 to adenine at position 199, (ii) 152 bases from adenine at position 250 to cytosine at position 401, or (iii) 52 bases from cytosine at position 808 to adenine at position 859, of the base sequence shown in SEQ ID NO: 1.
Claim 2
Dependent Claim
56 words
An antisense compound according to claim 1 characterized in that said base sequence is extracted from: (iv) 54 bases from guanine at position 127 to guanine at position 180, (v) 34 bases from adenine at position 284 to thymine at position 317, or (vi) 34 bases from cytosine at position 343 to cytosine at position 376.
Claim 3
Dependent Claim
26 words
An antisense compound according to claim 1 characterized in that said base sequence contains 8 bases from cytosine at position 830 to guanine at position 837.
Claim 4
Dependent Claim
185 words
An antisense compound according to claim 1 characterized in that said base sequence is selected from: (1) a base sequence which is included within 54 bases from guanine at position 127 to guanine at position 180, and which contains 16 bases from cytosine at position 131 to adenine at position 146, 7 bases from cytosine at position 147 to cytosine at position 153, 6 bases from cytosine at position 151 to cytosine at position 156, or 6 bases from cytosine at position 175 to guanine at position 180, (2) a base sequence which is included within 34 bases from adenine at position 284 to thymine at position 317, and which contains 5 bases from guanine at position 285 to thymine at position 289, or 6 bases from thymine at position 309 to thymine at position 314, and (3) a base sequence which is included within 34 bases from cytosine at position 343 to cytosine at position 376, and which contains 5 bases from guanine at position 355 to adenine at position 359, or 5 bases from adenine at position 369 to guanine at position 373.
Claim 5
Dependent Claim
427 words
An antisense compound according to claim 4 characterized in that said base sequence is selected from: (4) a base sequence consisting of 16-24 bases which is included within 24 bases from guanine at position 127 to cytosine at position 150, and which contains at least 16 bases from cytosine at position 131 to adenine at position 146, (5) a base sequence consisting of 15-30 bases which is included within 49 bases from guanine at position 127 to cytosine at position 175, and which contains at least 7 bases from cytosine at position 147 to cytosine at position 153, (6) a base sequence consisting of 15-30 bases which is included within 31 bases from cytosine at position 150 to guanine at position 180, and which contains at least 6 bases from cytosine at position 151 to cytosine at position 156, (7) a base sequence consisting of 15-30 bases which is included within 31 bases from cytosine at position 150 to guanine at position 180, and which contains at least 6 bases from cytosine at position 175 to guanine at position 180, (8) a base sequence consisting of 15-33 bases which is included within 34 bases from adenine at position 284 to thymine at position 317, and which contains at least 5 bases from guanine at position 285 to thymine at position 289, (9) a base sequence consisting of 15-33 bases which is included within 34 bases from adenine at position 284 to thymine at position 317, and which contains at least 6 bases from thymine at position 309 to thymine at position 314, (10) a base sequence consisting of 15-30 bases which is included within 34 bases from cytosine at position 343 to cytosine at position 376, and which contains at least 5 bases from guanine at position 355 to adenine at position 359, (11) a base sequence consisting of 15-30 bases which is included within 34 bases from cytosine at position 343 to cytosine at position 376, and which contains at least 5 bases from adenine at position 369 to guanine at position 373. (12) a base sequence consisting of 15-26 bases which is included within 26 bases from thymine at position 351 to cytosine at position 376, and which contains at least 5 bases from guanine at position 355 to adenine at position 359, and (13) a base sequence consisting of 15-26 bases which is included within 26 bases from thymine at position 351 to cytosine at position 376, and which contains at least 5 bases from adenine at position 369 to guanine at position 373.
Claim 6
Dependent Claim
34 words
An antisense compound according to claim 5 characterized in that said base sequence consists of 15-20 bases and is extracted from the 20 bases from cytosine at position 139 to guanine at position 158.
Claim 7
Dependent Claim
29 words
An antisense compound according to claim 5 characterized in that said base sequence is represented by the 30 bases from cytosine at position 151 to guanine at position 180.
Claim 8
Dependent Claim
29 words
An antisense compound according to claim 5 characterized in that said base sequence is represented by the 20 bases from cytosine at position 131 to cytosine at position 150.
Claim 9
Dependent Claim
29 words
An antisense compound according to claim 5 characterized in that said base sequence is represented by the 19 bases from cytosine at position 141 to guanine at position 159.
Claim 10
Dependent Claim
29 words
An antisense compound according to claim 5 characterized in that said base sequence is represented by the 20 bases from guanine at position 355 to cytosine at position 374.
Claim 11
Dependent Claim
29 words
An antisense compound according to claim 5 characterized in that said base sequence is represented by the 20 bases from thymine at position 353 to adenine at position 372.
Claim 12
Dependent Claim
18 words
An anti-hepatitis virus C formulation which comprises as an active ingredient an antisense compound according to claim 1.
References Cited (Backward Citations)
EP0388232A1
Cited
WO1992012992A2
Cited
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