EP0611822A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
More complex type retroviruses having mixed type LTR, and uses thereof
Assignee: Wisconsin Alumni Research Foundation
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Filing: 1994-02-17
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Granted: —
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Expires: 2014-02-17
Abstract
Abstract A recombinant retrovirus comprising an RNA sequence having simpler (S) Type retroviral long termini; a more complex (MC) Type att , pbs , E and ppt RNA sequence; and an RNA sequence encoding an MC Type retroviral protein selected from human immunodeficiency virus proteins, human spumaretrovirus proteins, human T-lymphotropic virus proteins and bovine leukemia virus proteins. The recombinant retrovirus is useful as a vaccine against MC Type retroviruses.
Inventors
- 👤 Howard M. Temin
- 👤 Kathleen A. Boris-Lawrie
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-03 10:19
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/005; A; A61; A61P; A61P31/00; A61P31/12; C12; C12N; C12N15/00; C12N15/09; C12N15/63; C12N15/79; C12N15/85; C12N15/86; A61K; A61K39/00; C12N2740/00; C12N2740/00011; C12N2740/10011; C12N2740/13011; C12N2740/13022; C12N2740/15011; C12N2740/15041; C12N2740/15043; C12N2830/00; C12N2830/50
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
53 words
A recombinant retroviral DNA sequence comprising a simpler (S) Type long terminal repeat; a more complex (MC) Type att , pbs , E and ppt sequence; and a sequence encoding a MC Type retroviral protein selected from human immunodeficiency virus proteins, human spumaretrovirus proteins, human T-lymphotropic virus proteins and bovine leukemia virus proteins.
Claim 2
Dependent Claim
15 words
A sequence according to claim 1 which does not comprise an S Type att sequence.
Claim 3
Dependent Claim
13 words
A sequence according to claim 1 or 2 encoding a replication competent retrovirus.
Claim 4
Dependent Claim
21 words
A sequence according to claim 1, 2 or 3 wherein the MC Type retroviral protein is Env, Gag or Pol protein.
Claim 5
Dependent Claim
56 words
A recombinant retrovirus comprising an RNA sequence having simpler (S) Type retroviral long termini; a more complex (MC) Type att , pbs , E and ppt RNA sequence; and an RNA sequence encoding an MC Type retroviral protein selected from human immunodeficiency virus proteins, human spumaretrovirus proteins, human T-lymphotropic virus proteins and bovine leukemia virus proteins.
Claim 6
Dependent Claim
10 words
A retrovirus according to claim 5 which is replication competent.
Claim 7
Dependent Claim
19 words
A retrovirus according to claim 5 or 6 wherein-the MC type retroviral protein is Env, Gag or Pol protein.
Claim 8
Dependent Claim
20 words
A vaccine comprising a retrovirus as claimed in claim 5, 6 or 7 and a physiologically acceptable carrier or diluent.
Claim 9
Dependent Claim
27 words
A retrovirus according to claim 5, 6 or 7, or a vaccine according to claim 8 for use in treating the human or animal body by therapy.
Claim 10
Dependent Claim
34 words
A retrovirus or vaccine according to claim 9 for use in inducing immunity against infection by a MC type retrovirus selected from human immunodeficiency virus, human spumaretrovirus, human T-lymphotropic virus and bovine leukemia virus.
References Cited (Backward Citations)
No citation records indexed.
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