EP0599646A2
Expired / Lapsed
EP
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Production of saccharide carboxylic acids
Assignee: Takeda Pharmaceutical Co Ltd
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Filing: 1993-11-25
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Granted: —
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Expires: 2013-11-25
Abstract
Abstract A process for producing a saccharide carboxylic acid or a salt thereof is characterised in that a microorganism belonging to the genus Pseudogluconobacter and capable of oxidizing a hydroxymethyl group and/or hemiacetal hydroxyl-associated carbon atom to a carboxyl group, or an artefact derived from the microorganism, is permitted to act on a hydroxymethyl and/or hemiacetal hydroxyl-containing saccharide or saccharide derivative to produce and accumulate the corresponding carboxylic acid, and the carboxylic acid so accumulated is harvested; novel saccharide carboxylic acids produced by the above production method, and by the process, from a broad range of saccharides, saccharic acids having carboxyl groups derived from hydroxymethyl and/or hemiacetal OH groups can be produced with high selectivity and in good yield; the resultant saccharide acids are resistant to enzymatic degradation and have improved water solubility, among other characteristics. <IMAGE>
Inventors
- 👤 Toshihiro Ishiguro
- 👤 Masahide Oka
- 👤 Takamasa Yamaguchi
- 👤 Ikuo Nogami
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-08 08:02
CPC Classifications
C; C07; C07H; C07H3/00; C07H3/04; C07H15/00; C07H15/02; C07H15/04; C07H15/20; C07H15/22; C07H15/24; C07H15/256; C07H3/06; C07H7/00; C07H7/02; C07H7/033; C08; C08B; C08B30/00; C08B30/12; C08B30/18; C08B31/00; C08B31/18; C08B37/00; C08B37/0006; C08B37/0009; C08B37/0012; C08B37/0021; C12; C12P; C12P19/00; C12P19/02; C12P19/04; C12P19/12; C12P19/44; C12P19/56; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
74 words
A process for producing a saccharide carboxylic acid or a salt thereof which comprises permitting a microorganism belonging to the genus Pseudoaluconobacter and capable of oxidizing a hydroxymethyl group and/or a hemiacetal hydroxyl-attached carbon atom to carboxyl group or a cell preparation obtained therefrom to act on a hydroxymethyl- and/or hemiacetal hydroxyl-containing monosaccharide derivative, oligosaccharide, oligosaccharide derivative, polysaccharide or polysaccharide derivative to produce and accumulate the corresponding carboxylic acid, and isolating said carboxylic acid.
Claim 2
Dependent Claim
65 words
A process for producing a saccharide carboxylic acid or a salt thereof which comprises permitting a microorganism belonging to the genus Pseudogluconobacter and capable of oxidizing a hydroxymethyl group to carboxyl group or a cell preparation obtained therefrom to act on a hydroxymethyl-containing monosaccharide derivative, oligosaccharide, oligosaccharide derivative, polysaccharide or polysaccharide derivative to produce and accumulate the corresponding carboxylic acid, and isolating said carboxylic acid.
Claim 3
Dependent Claim
21 words
The process according to claim 1 or 2 wherein the cell itself of said microorganism of the genus Pseudogluconobacter is employed.
Claim 4
Dependent Claim
23 words
A saccharide carboxylic acid such that at least one hydroxymethyl group of palatinose has been oxidized to carboxyl group or a salt thereof.
Claim 5
Dependent Claim
23 words
A saccharide carboxylic acid such that at least one hydroxymethyl group of D-trehalose has been oxidized to carboxyl group or a salt thereof.
Claim 6
Dependent Claim
23 words
A saccharide carboxylic acid such that at least one hydroxymethyl group of maltosyl-β-cyclodextrin has been oxidized to carboxyl group or a salt thereof.
Claim 7
Dependent Claim
24 words
A saccharide carboxylic acid such that at least one hydroxymethyl group of 2-O-α-D-glucopyranosyl-L-ascorbic acid has been oxidized to carboxyl group or a salt thereof.
Claim 8
Dependent Claim
23 words
A saccharide carboxylic acid such that at least one hydroxymethyl group of streptozotocin has been oxidized to carboxyl group or a salt thereof.
Claim 9
Dependent Claim
23 words
A saccharide carboxylic acid such that at least one hydroxymethyl group of heptulose has been oxidized to carboxyl group or a salt thereof.
Claim 10
Dependent Claim
26 words
A saccharide carboxylic acid such that at least one hydroxymethyl group of maltodextrin of formula (I) has been oxidized to carboxyl group or a salt thereof.
Claim 11
Dependent Claim
36 words
A saccharide carboxylic acid such that at least one hydroxymethyl group of a steviol glycoside of formula [wherein R₁=-β-Glc-2-β-Glc, -β-Glc-2-α-Rha, or -β-Glc; R₂=-β-Glc or - β-Glc-2-β-Glc has been oxidized to carboxyl group or a salt thereof.
Claim 12
Dependent Claim
29 words
The saccharide carboxylic acid or salt of claim 11 wherein the steviol glycoside isastevioside of the formula (II) in which R₁ and R₂ stand for -β-Glc-2-β-Glc and -β-Glc, respectively.
Claim 13
Dependent Claim
28 words
The saccharide carboxylic acid or salt of claim 11 wherein the steviol glycoside is rebaudioside-A of the formula in which R₁ and R₂ stand for and -β-Glc, respectively.
Claim 14
Dependent Claim
24 words
A saccharide carboxylic acid such that at least one hydroxymethyl group of validamycin A has been oxidized to carboxyl group or a salt thereof.
Claim 15
Dependent Claim
23 words
A saccharide carboxylic acid such that at least one hydroxymethyl group of mogroside has been oxidized to carboxyl group or a salt thereof.
Claim 16
Dependent Claim
23 words
A saccharide carboxylic acid such that at least one hydroxymethyl group of dextran has been oxidized to carboxyl group or a salt thereof.
Claim 17
Dependent Claim
18 words
A complex of a saccharide carboxylic acid or a salt thereof of claim 16 with a metal salt.
Claim 18
Dependent Claim
68 words
A process for producing a saccharide carboxylic acid or a salt thereof which comprises permitting a microorganism belonging to the genus Pseudoaluconobacter and capable of oxidizing a hemiacetal hydroxyl-attached carbon atom to carboxyl group, or a cell preparation obtained therefrom to act on a hemiacetal hydroxyl-containing monosaccharide derivative, oligosaccharide, oligosaccharide derivative, polysaccharide or polysaccharide derivative to produce and accumulate the corresponding carboxylic acid, and isolating said carboxylic acid.
Claim 19
Dependent Claim
19 words
The process of claim 18 wherein the cell itself of said microorganism belonging to the genus Pseudogluconobacter is employed.
Claim 20
Dependent Claim
12 words
The process of claim 18 wherein the hemiacetal hydroxyl-containing polysaccharide is dextran.
Claim 21
Dependent Claim
14 words
The process of claim 18 wherein the hemiacetal hydroxyl-containing polysaccharide derivative is dextranylglucuronic acid.
Claim 22
Dependent Claim
24 words
A saccharide carboxylic acid such that at least one hemiacetal hydroxyl group-attached carbon atom has been oxidized to carboxyl group or a salt thereof.
Claim 23
Dependent Claim
16 words
A complex of the saccharide carboxylic acid or salt of claim 22 with a metal salt.
Claim 24
Dependent Claim
18 words
A process for producing a dextranylglucuronic acid-iron hydroxide complex which comprises reacting dextranylglucuronic acid with ferric hydroxide sol.
Claim 25
Dependent Claim
11 words
The process of claim 1 wherein the hydroxylmethyl-containing oligosaccharide is sucrose.
References Cited (Backward Citations)
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