EP0592836A1
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EP
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Human adeno-associated virus integration site DNA and uses thereof
Assignee: Wyeth Holdings LLC
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Filing: 1993-09-16
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Granted: —
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Expires: 2013-09-16
Abstract
Abstract The present invention relates to an isolated nucleic acid fragment comprising a nucleic acid sequence corresponding to a human AAV integration site, or a subsequence thereof which is site specific to the AAV integration site.
Inventors
- 👤 Robert Michael Kotin
- 👤 Kenneth Ira Berns
- 👤 Ralph Michael Linden
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-09 23:15
CPC Classifications
C; C12; C12N; C12N15/00; C12N15/09; C12N15/63; C12N15/79; C12N15/85; C12N15/86; C07; C07K; C07K14/00; C07K14/005; A; A61; A61K; A61K48/00; C12N2750/00; C12N2750/00011; C12N2750/14011; C12N2750/14111; C12N2750/14122; C12N2750/14141; C12N2750/14143
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
17 words
An isolated nucleic acid fragment comprising a nucleic acid sequence corresponding to a human AAV integration site.
Claim 2
Dependent Claim
10 words
The fragment of Claim 1 which is about 4 kb.
Claim 3
Dependent Claim
18 words
The fragment of Claim 1 which comprises the sequence depicted Figure 1, or a site specific subsequence thereof.
Claim 4
Dependent Claim
30 words
The fragment of Claim 1 which consists essentially of a site specific subsequence selected from the group consisting of RML1, RML2, RML5, RK1, RK2, RK3, KL1, KL2, KL3 and KL4.
Claim 5
Dependent Claim
20 words
The fragment of Claim 1 which consists essentially of the nucleotides 1620-2318 as depicted in Figure 1, or subsequences thereof.
Claim 6
Dependent Claim
38 words
An isolated structural gene having the following characteristics: (a) a TATA-less promoter; (b) a cAMP responsive element; (c) three SP1-like binding sites; (d) at least nine UBF1 sequences within a CpG island; (e) is isolatable from chromosome 19.
Claim 7
Dependent Claim
20 words
The gene of Claim 6 which comprises the sequence corresponding to nucleotides 1620 to 2318 as depicted in Figure 1.
Claim 8
Dependent Claim
9 words
A recombinant vector comprising the fragment of Claim 1.
Claim 9
Dependent Claim
9 words
A recombinant vector comprising the gene of Claim 5.
Claim 10
Dependent Claim
13 words
A recombinantly produced protein comprising the amino acid sequence encoded by nucleotides 1620-2318.
References Cited (Backward Citations)
No citation records indexed.
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