EP0532348A2
Expired / Lapsed
EP
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A tramadol N-oxide material, enantiomers and compositions thereof, and their use
Assignee: Janssen Pharmaceuticals Inc
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Filing: 1992-09-11
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Granted: —
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Expires: 2012-09-11
Abstract
Abstract This invention relates to a tramadol N-oxide material, enantiomers and compositions thereof and their use. The tramadol N-oxide material and compositions thereof are pharmacologically useful in treating pain, diarrhea and tussive conditions. The tramadol N-oxide is also subject to less side-effects as compared to pure opiate based compositions, such as abuse liability, tolerance, constipation and respiratory depression. Furthermore, the tramadol N-oxide material when administered orally exhibits analgesia for a longer duration than an equi-analgesic amount of tramadol.
Inventors
- 👤 Cynthia A. Maryanoff
- 👤 Frank J. Villani
- 👤 Robert B. Raffa
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-04 12:35
CPC Classifications
C; C07; C07C; C07C291/00; C07C291/02; C07C291/04; A; A61; A61P; A61P1/00; A61P1/12; A61P11/00; A61P11/14; A61P25/00; A61P25/04; C07C2601/00; C07C2601/12; C07C2601/14
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
6 words
A compound of the formula I:
Claim 2
Dependent Claim
6 words
A compound of the formula I:
Claim 3
Dependent Claim
12 words
An enantiomer of the compound of claim 1 having the formula II:
Claim 4
Dependent Claim
12 words
An enantiomer of the compound of claim 1 having the formula III:
Claim 5
Dependent Claim
24 words
A pharmaceutical composition comprising the compound if any one of claims 1 to 3 in a therapeutically effective amount and a pharmaceutically acceptable carrier.
Claim 6
Dependent Claim
26 words
The compound of any one of claims 1 to 3 or the composition of claim 4, for use in treating a pharmacological condition in a mammal.
Claim 7
Dependent Claim
24 words
The compound of any one of claims 1 to 3 or the composition of claim 4, for use in treating pain in a mammal.
Claim 8
Dependent Claim
27 words
The compound of any one of claims 1 to 3 or the composition of claim 4, for use in providing a long acting analgesia in a mammal.
References Cited (Backward Citations)
No citation records indexed.
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