Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
23 words
A rearranged taxol compound having the following structure: wherein R1 is C(O)CH₃, R2 is H or Si(CH₂CH₃)₃, and R3 is H or Si(CH₂CH₃)₃.
Claim 2
Dependent Claim
25 words
A taxol compound having the following structure: wherein R1 is C(O)CH₃, R2 is H or OSi(CH₂CH₃)₃, R3 is OSO₂CH₃, and R4 is H or Si(CH₂CH₃)₃.
Claim 3
Dependent Claim
19 words
A rearranged taxol compound having the following structure: wherein R1 is H or C(O)CH₃, R2 is H or C(O)CH₃.
Claim 4
Dependent Claim
33 words
A process for producing taxol compounds with an A-ring contracted to five members, comprising the steps of: (a) protecting hydroxylated positions on taxol; and (b) reacting said protected taxol with a mesyl halide.
Claim 5
Dependent Claim
18 words
A process according to claim 4, further comprising the step of deprotecting said protected taxol to form A-Nor-taxol.
Claim 6
Dependent Claim
40 words
A process for producing taxol compounds with an A-ring contracted to five members, comprising the steps of: (a) reacting taxol with a trialkylsilyl halide to form a taxol silyl ether; and (b) reacting taxol silyl ether with a mesyl halide.
Claim 7
Dependent Claim
26 words
A process according to claim 6, further comprising the step of: (c) following step (b) removing silyl groups on said taxol silyl ether to yield A-Nor-taxol.
Claim 8
Dependent Claim
19 words
The process of claim 7, wherein step (c) is carried out by reacting said silylated A-Nor-taxol with pyridinium hydrofluoride.
Claim 9
Dependent Claim
20 words
The process of claim 6, 7 or 8, wherein said steps (a) and (b) are carried out in basic conditions.
Claim 10
Dependent Claim
24 words
The process of any one of claims 6, to 9, wherein said trialkylsiyl halide is triethylsilyl chloride, and said mesyl halide is mesyl chloride.
Claim 11
Dependent Claim
44 words
A process for producing rearranged taxol compounds comprising the reaction of taxol with an oxonium compound to form a taxol compound with an opened oxetane ring; and reacting said taxol compound with an opened oxetane ring with dimethoxypropane in the presence or p-toluenesulfonic acid.
Claim 12
Dependent Claim
12 words
The process of claim 11, wherein said oxonium compound is triethyloxonium tetrafluoroborate.
Claim 13
Dependent Claim
64 words
A process for determining the bioactivity of a compound,comprising treatment of an unknown compound in a bioactivity test and treatment under the same conditions of at least one of the compounds selected from the group comprised of A-Nor-taxol, a taxol compound with an opened oxetane ring, and a taxol compound with an opened oxetane ring and a five member A-ring fused to the B-ring.
Claim 14
Dependent Claim
14 words
A cytotoxic agent comprising a taxol compound having an A-ring contracted to five members.
Claim 15
Dependent Claim
15 words
The cytotoxic agent of claim 14, wherein said taxol compound has an intact oxetane D-ring.