EP0503853A2
Expired / Lapsed
EP
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Water soluble polymeric thickeners for products for topical application
Assignee: Scott Bader Co Ltd
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Filing: 1992-03-06
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Granted: —
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Expires: 2012-03-06
Abstract
Abstract A thickener for products for topical application such as personal care products for application to the skin or hair, or topically administrable pharmaceutical preparations, comprises a water-in-oil emulsion containing polymeric material, at least 98% of which polymeric material is soluble in the aqueous phase. The polymeric material comprises units derived from (a) acrylamide, (b) 2-acrylamido-2-methylpropane-sulphonic acid (AMPS) and (c) a polyfunctional monomer, present in an amount of from 0.12 to 2 milliequivalents per mol of total monomer units. At least some of the AMPS units are in the form of a neutral salt such that the aqueous phase of the water in oil emulsion has a pH of at least 5.5.
Inventors
- 👤 Roman Joseph Mikolajewicz
- 👤 Arshad-Ul-Haq Chaudhry
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-01 13:24
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/02; A61K8/04; A61K8/06; A61K8/064; A61K47/00; A61K47/30; A61K47/32; A61K8/18; A61K8/72; A61K8/81; A61K8/8141; A61K8/8158; A61K9/00; A61K9/0012; A61K9/0014; A61K9/10; A61K9/107; A61Q; A61Q19/00; A61Q5/00; A61K2800/00; A61K2800/40; A61K2800/48; A61Q19/002
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
118 words
A method of preparing a composition for topical application, which method comprises admixing a topically acceptable, liquid-containing, formulation containing a topically acceptable adjuvant with a water in oil emulsion containing polymeric material, at least 98% of the polymeric material in the emulsion being water soluble, which polymeric material comprises units derived from (a) acrylamide, (b) 2-acrylamido-2-methyl-propanesulphonic acid and (c) a polyfunctional monomer, which polyfunctional monomer is present in an amount of from 0.12 to 2 milliequivalents inclusive per mole of total monomer units, at least some of the 2-acrylamido-2-methylpropanesulphonic acid units being in the form of a neutral salt thereof such that the aqueous phase of the water in oil emulsion has a pH of at least 5.5.
Claim 2
Dependent Claim
40 words
A method according to claim 1, wherein the water in oil emulsion has a polymer content and a pH at which at least 98% of the polymeric material is dissolved in the aqueous phase of the water in oil emulsion.
Claim 3
Dependent Claim
34 words
A method according to claim 1 or claim 2, in which the polyfunctional monomer (c) in the water in oil emulsion is selected from at least one of allyl sucrose, allyl pentaerythritol and methylene-bisacrylamide.
Claim 4
Dependent Claim
12 words
A method according to claim 3, wherein the polyfunctional monomer is methylene-bisacrylamide.
Claim 5
Dependent Claim
39 words
A method according to claim 4, wherein the methylene-bisacrylamide is present in the water in oil emulsion in an amount of from 0.08 to 0.7 m.mole per 1 mole of the total of the monomer units (a) and (b).
Claim 6
Dependent Claim
40 words
A method according to claim 5, wherein the methylene- bisacrylamide is present in the water in oil emulsion in an amount of from 0.1 to 0.4 m.mole per 1 mole of the total of the monomer units (a) and (b).
Claim 7
Independent Claim
34 words
A method according to any preceding claim in which the monomer units (a) and (b) are present in the water in oil emulsion in a molar ratio (a)/(b) of from 85/15 to 15/85 inclusive.
Claim 8
Independent Claim
33 words
A method according to any preceding claim, wherein the water in oil emulsion contains, as a neutralizing agent, at least one of sodium and potassium hydroxides and water soluble and water miscible amines.
Claim 9
Independent Claim
36 words
A method according to any preceding claim, wherein the composition for topical application additionally contains an oil in water emulsifying agent comprising at least one emulsifier and having a hydrophile lipophile balance of at least 10.
Claim 10
Independent Claim
17 words
A method according to any preceding claim, wherein the topically acceptable adjuvant comprises an alcohol and/or glycol.
Claim 11
Independent Claim
176 words
A method according to any preceding claim, which includes the preliminary step of preparing the water in oil emulsion containing the polymeric material, at least 98% of the polymeric material in the emulsion being water soluble, which preliminary step comprises forming, with the assistance of a water in oil emulsifier, a water in oil emulsion of a monomer composition, in which water in oil emulsion the concentration of total monomer, by weight of the total of the water in oil emulsion and monomer composition, is at least 30 weight % and which monomer composition comprises (a) acrylamide, (b) 2-acrylamido-2-methylpropanesulphonic acid and (c) a polyfunctional monomer, which polyfunctional monomer is present in the monomer composition in an amount of 0.12 to 2 milliequivalents inclusive per mole of total monomer units, at least some of the 2-acrylamido-2-methylpropanesulphonic acid being in the form of a neutral salt thereof such that the aqueous phase of the water in oil emulsion containing the monomer composition has a pH of at least 5.5, and subjecting the monomer composition to inverse emulsion polymerisation.
Claim 12
Dependent Claim
89 words
A composition for topical application comprising a topically acceptable liquid phase comprising an aqueous medium, a polymeric material at least 98% of which is water soluble, which polymeric material comprises units derived from (a) acrylamide, (b) 2-acrylamido-2-methylpropanesulphonic acid and (c) a polyfunctional monomer, which polyfunctional monomer is present in an amount of from 0.12 to 2 milliequivalents inclusive per mole of total monomer units, an oil phase, a water in oil emulsifier, an oil in water emulsifier, and a topically acceptable adjuvant, optionally forming part of the liquid phase.
Claim 13
Dependent Claim
25 words
A personal care product which is a composition according to claim 12, wherein the topically acceptable liquid phase additionally comprises an alcohol and/or a glycol.
Claim 14
Dependent Claim
21 words
A pharmaceutical composition for topical application which is a composition according to claim 12, which additionally contains a pharmaceutically active component.
Claim 15
Dependent Claim
19 words
A composition according to any one of claims 12 to 14 which has a pH of at least 5.
Claim 16
Dependent Claim
15 words
A composition according to any one of claims 12 to 15 which is a cream.
Claim 17
Dependent Claim
15 words
A composition according to any one of claims 12 to 15 which is a gel.
Claim 18
Dependent Claim
94 words
A water in oil emulsion containing polymeric material, at least 98% of the polymeric material in the emulsion being water soluble, which polymeric material comprises units derived from (a) acrylamide, (b) 2-acrylamido-2-methyl-propanesulphonic acid and (c) a polyfunctional monomer, which polyfunctional monomer is present in an amount of from 0.12 to 2 milliequivalents inclusive per mole of total monomer units, at least some of the 2-acrylamido-2-methylpropanesulphonic acid units being in the form of a neutral salt thereof such that the aqueous phase of the water in oil emulsion has a pH of at least 5.5.
Claim 19
Dependent Claim
32 words
A water in oil emulsion according to claim 18, which has a polymer content and a pH at which at least 98% of the polymeric material is dissolved in the aqueous phase.
Claim 20
Dependent Claim
36 words
A water in oil emulsion according to claim 18 or 19, in which the polyfunctional monomer (c) in the water in oil emulsion is selected from at least one of allyl sucrose, allyl pentaerythritol and methylene-bisacrylamide.
Claim 21
Dependent Claim
15 words
A water in oil emulsion according to claim 20, wherein the polyfunctional monomer is methylene-bis-acrylamide.
Claim 22
Dependent Claim
42 words
A water in oil emulsion according to claim 21, wherein the methylene-bisacrylamide is present in the water in oil emulsion in an amount of from 0.06 to 1 m.mole per 1 mole of the total of the monomer units (a) and (b).
Claim 23
Dependent Claim
42 words
A water in oil emulsion according to claim 22, wherein the methylene-bisacrylamide is present in the water in oil emulsion in an amount of from 0.1 to 0.4 mole per 1 mole of the total of the monomer units (a) and (b).
Claim 24
Dependent Claim
35 words
A water in oil emulsion according to any one of claims 18 to 23, in which the monomer units (a) and (b) are present in a molar ratio (a)/(b) of from 85/15 to 15/85 inclusive.
Claim 25
Dependent Claim
34 words
A water in oil emulsion according to any one of claims 18 to 24, containing, as a neutralizing agent, at least one of sodium and potassium hydroxides and water soluble and water miscible amines.
Claim 26
Dependent Claim
38 words
A water in oil emulsion according to any one of claims 18 to 25, which additionally contains an oil in water emulsifying agent comprising at least one emulsifier and having a hydrophile lipophile balance of at least 10.
Claim 27
Independent Claim
155 words
A method of preparing a water in oil emulsion containing polymeric material, at least 98% of the polymeric material in the emulsion being water soluble, which process comprises forming a water in oil emulsion of a monomer composition, in which water in oil emulsion the concentration of total monomer, by weight of the total of the water in oil emulsion and monomer composition, is at least 30 weight % and which monomer composition comprises (a) acrylamide, (b) 2-acrylamido-2-methylpropanesulphonic acid and (c) a polyfunctional monomer, which polyfunctional monomer is present in the monomer composition in an amount of 0.12 to 2 milliequivalents inclusive per mole of total monomer units, at least some of the 2-acrylamido-2-methylpropanesulphonic acid being in the form of a neutral salt thereof such that the aqueous phase of the water in oil emulsion containing the monomer composition has a pH of at least 5.5, and subjecting the monomer composition to inverse emulsion polymerisation.
References Cited (Backward Citations)
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